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• W2200564614 abstract "Abstract Antibody‐drug conjugates (ADCs) are a growing class of anticancer agents combining the targeting ability of an antibody with the potency of a cytotoxic agent. Ado‐trastuzumab emtansine (Kadcyla ® , or Trastuzumab‐DM1 (T‐DM1)) is approved for the treatment of human epidermal growth factor receptor 2+ (HER2+) metastatic breast cancer and in development for other HER2+ indications. This chapter explores the pharmacokinetic/pharmacodynamic (PK/PD) and absorption, distribution, metabolism, and excretion (ADME) strategy and data for T‐DM1. In the course of the development of T‐DM1, a substantial body of information was generated describing the ADME characteristics of the ADC. The strategy was to develop a comprehensive understanding of the behavior of T‐DM1, including its PK/PD, distribution, in vivo and ex vivo stability, catabolic fate, and excretion. The foundation upon which PK and ADME evaluation is built is thorough and robust bioanalytical methods capable of determining the presence of key components of the molecule of interest." @default.
• W2200564614 created "2016-06-24" @default.
• W2200564614 creator A5032746475 @default.
• W2200564614 date "2015-12-30" @default.
• W2200564614 modified "2023-09-26" @default.
• W2200564614 title "Investigating the Nonclinical <scp>ADME</scp> and <scp>PK/PD</scp> of an Antibody–Drug Conjugate: A Case Study of Ado‐Trastuzumab Emtansine ( <scp>T‐DM1</scp> )" @default.
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• W2200564614 doi "https://doi.org/10.1002/9780470571224.pse561" @default.
• W2200564614 hasPublicationYear "2015" @default.
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