FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2200568854> ?p ?o ?g. }

• W2200568854 endingPage "6" @default.
• W2200568854 startingPage "20" @default.
• W2200568854 abstract "To analyze which factors allow to assess the risk of finding a prostate cancer (PCa) at repeated biopsies in patients with diagnosis of prostatic intraepithelial neoplasia (PIN).At our institute all patients with a diagnosis of PIN undergo a 6-monthly control biopsy until the achievement of a benign histology or up to a maximum of 4 consecutive biopsies. For this study a retrospective review of clinical and bioptic data of patients with a diagnosis of isolated PIN (i.e. without associated atypical small acinar proliferation or small cancer foci) was carried out. The correlation between these features and the probability to find PCa at the first re-biopsy or at a further re-biopsy was independently analyzed.The data of 546 patients subjected to a median number of 3 biopsies, (mean: 10.8 and 12.9 cores at initial biopsy and at first re-biopsy, respectively), and with a mean “bioptic” follow-up time of 14.8 months, were analyzed. PCa was found in 174 cases (31.8%): for 116 of them it took place at the first re-biopsy, with a mean latency of 7.8 months from PIN diagnosis, whereas for 58 at a further re-biopsy, with a mean latency of 21.6 months. The risk of diagnosing PCa at the first re-biopsy was statistically correlated with the PSA value--for which a cut-off value of 7 ng/mL was identified--and with an anomalous rectal prostatic examination at the time of the initial biopsy. Differently, the risk of diagnosing PCa after the first re-biopsy correlated with the number of cores positive for PIN at the initial biopsy--for which a cut-off of 4 was identified--and to the ratio between these and the total number of cores, defined as PIN density--for which a cut-off of 50% was determined. DISCUSSION AND CONCLUSIONS. It is possible to suggest a tailored protocol of controls in patients with a diagnosis of PIN on the basis of the data available at the initial biopsy: a) high PSA value and/or an anomalous prostatic rectal examination: the diagnosis of PCa is probably just unacknowledged by the initial sampling and it is advisable to carry out an early re-biopsy; b) number of cores with PIN equal to or higher than 4 and/or PIN density equal to or higher than 50%: a true transition from PIN to PCa is likely to happen with time and it is advisable to carry out a delayed re-biopsy; c) no risk factors: just clinical and PSA monitoring to establish the indication to re-biopsy." @default.
• W2200568854 created "2016-06-24" @default.
• W2200568854 creator A5013860122 @default.
• W2200568854 creator A5014715103 @default.
• W2200568854 creator A5026764992 @default.
• W2200568854 creator A5027682415 @default.
• W2200568854 creator A5047044393 @default.
• W2200568854 creator A5070567916 @default.
• W2200568854 creator A5077837993 @default.
• W2200568854 creator A5079215275 @default.
• W2200568854 creator A5080988702 @default.
• W2200568854 date "2011-06-17" @default.
• W2200568854 modified "2023-10-05" @default.
• W2200568854 title "[Which factors allow to anticipate the diagnosis of prostate cancer in pin patients? A study on 546 patients]." @default.
• W2200568854 cites W1506654624 @default.
• W2200568854 cites W1965124667 @default.
• W2200568854 cites W1979008650 @default.
• W2200568854 cites W1983690106 @default.
• W2200568854 cites W1988913944 @default.
• W2200568854 cites W1996388835 @default.
• W2200568854 cites W2002471362 @default.
• W2200568854 cites W2026327944 @default.
• W2200568854 cites W2035121472 @default.
• W2200568854 cites W2041508773 @default.
• W2200568854 cites W2045747371 @default.
• W2200568854 cites W2058009055 @default.
• W2200568854 cites W2077928657 @default.
• W2200568854 cites W2084197013 @default.
• W2200568854 cites W2089661954 @default.
• W2200568854 cites W2096071102 @default.
• W2200568854 cites W2099961351 @default.
• W2200568854 cites W2123230901 @default.
• W2200568854 cites W2126559236 @default.
• W2200568854 cites W2128536507 @default.
• W2200568854 cites W2155693336 @default.
• W2200568854 cites W2157395875 @default.
• W2200568854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21678580" @default.
• W2200568854 hasPublicationYear "2011" @default.
• W2200568854 type Work @default.
• W2200568854 sameAs 2200568854 @default.
• W2200568854 citedByCount "0" @default.
• W2200568854 crossrefType "journal-article" @default.
• W2200568854 hasAuthorship W2200568854A5013860122 @default.
• W2200568854 hasAuthorship W2200568854A5014715103 @default.
• W2200568854 hasAuthorship W2200568854A5026764992 @default.
• W2200568854 hasAuthorship W2200568854A5027682415 @default.
• W2200568854 hasAuthorship W2200568854A5047044393 @default.
• W2200568854 hasAuthorship W2200568854A5070567916 @default.
• W2200568854 hasAuthorship W2200568854A5077837993 @default.
• W2200568854 hasAuthorship W2200568854A5079215275 @default.
• W2200568854 hasAuthorship W2200568854A5080988702 @default.
• W2200568854 hasConcept C121608353 @default.
• W2200568854 hasConcept C126322002 @default.
• W2200568854 hasConcept C126838900 @default.
• W2200568854 hasConcept C141071460 @default.
• W2200568854 hasConcept C167135981 @default.
• W2200568854 hasConcept C2775934546 @default.
• W2200568854 hasConcept C2776235491 @default.
• W2200568854 hasConcept C2779534503 @default.
• W2200568854 hasConcept C2780192828 @default.
• W2200568854 hasConcept C2781217009 @default.
• W2200568854 hasConcept C71924100 @default.
• W2200568854 hasConceptScore W2200568854C121608353 @default.
• W2200568854 hasConceptScore W2200568854C126322002 @default.
• W2200568854 hasConceptScore W2200568854C126838900 @default.
• W2200568854 hasConceptScore W2200568854C141071460 @default.
• W2200568854 hasConceptScore W2200568854C167135981 @default.
• W2200568854 hasConceptScore W2200568854C2775934546 @default.
• W2200568854 hasConceptScore W2200568854C2776235491 @default.
• W2200568854 hasConceptScore W2200568854C2779534503 @default.
• W2200568854 hasConceptScore W2200568854C2780192828 @default.
• W2200568854 hasConceptScore W2200568854C2781217009 @default.
• W2200568854 hasConceptScore W2200568854C71924100 @default.
• W2200568854 hasLocation W22005688541 @default.
• W2200568854 hasLocation W22005688542 @default.
• W2200568854 hasOpenAccess W2200568854 @default.
• W2200568854 hasPrimaryLocation W22005688541 @default.
• W2200568854 hasRelatedWork W2075763133 @default.
• W2200568854 hasRelatedWork W2079711863 @default.
• W2200568854 hasRelatedWork W2088520467 @default.
• W2200568854 hasRelatedWork W2107474944 @default.
• W2200568854 hasRelatedWork W2376423713 @default.
• W2200568854 hasRelatedWork W2566665866 @default.
• W2200568854 hasRelatedWork W4220759998 @default.
• W2200568854 hasRelatedWork W4225256611 @default.
• W2200568854 hasRelatedWork W4229597397 @default.
• W2200568854 hasRelatedWork W1583600832 @default.
• W2200568854 hasVolume "77 Suppl 17" @default.
• W2200568854 isParatext "false" @default.
• W2200568854 isRetracted "false" @default.
• W2200568854 magId "2200568854" @default.
• W2200568854 workType "article" @default.