FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2200599097> ?p ?o ?g. }

• W2200599097 abstract "This study aims to better define prognostic factors for patients with metastatic urothelial carcinoma (mUC), and to identify patients who will benefit from first-line cisplatin-based chemotherapy. We test the hypothesis that early objective response (EOR), defined as the occurrence of an objective response following 2 or 3 courses of chemotherapy, could be a prognostic factor for overall survival (OS) and thus be used to guide treatment decisions. Data from 113 patients with evaluable mUC receiving first-line cisplatin-based treatment between January 2004 and December 2006 was collected retrospectively from prospectively-maintained databases across seven French cancer centers. Clinical factors potentially associated with survival and EOR were analyzed in univariate and multivariate analysis. One hundred three patient records were complete and available for inclusion in the multivariate model. Four factors were independently associated with OS: Performance status 1 and 2 (HR 2.3 [95 % CI 1.3–3.9], p = 0.002; HR 3.4 [95 % CI 1.6–7.2], p = 0.001 respectively); presence of visceral metastases (HR 2.2 [95 % CI 1.3–3.9], p = 0.004); abnormal hemoglobin levels (HR 1.7 [95 % CI 1.01–2.8], p = 0.045); disease progression (HR 10.1 [95 % CI 4.2–24.1], p < 0.001). This study confirms the prognostic factors previously reported in first-line chemotherapy for mUC. However, we failed to demonstrate that EOR was an independent predictive factor of OS. Nevertheless, an early response evaluation is recommended since early progression is an important parameter that can be used to decide whether treatment should be interrupted and changed for alternative strategies integrating the concept of personalized medicine or new immune therapies." @default.
• W2200599097 created "2016-06-24" @default.
• W2200599097 creator A5001456598 @default.
• W2200599097 creator A5005874703 @default.
• W2200599097 creator A5010120065 @default.
• W2200599097 creator A5038456224 @default.
• W2200599097 creator A5047019507 @default.
• W2200599097 creator A5047763206 @default.
• W2200599097 creator A5065732872 @default.
• W2200599097 creator A5068223483 @default.
• W2200599097 creator A5073523132 @default.
• W2200599097 creator A5076354847 @default.
• W2200599097 creator A5084236822 @default.
• W2200599097 creator A5090993023 @default.
• W2200599097 date "2015-11-10" @default.
• W2200599097 modified "2023-10-14" @default.
• W2200599097 title "Early objective response may not be a prognostic factor of survival for patients with metastatic urothelial carcinoma: from a retrospective analysis of a cohort of 113 patients" @default.
• W2200599097 cites W1820014750 @default.
• W2200599097 cites W1857682357 @default.
• W2200599097 cites W1893740135 @default.
• W2200599097 cites W1971208896 @default.
• W2200599097 cites W1972705109 @default.
• W2200599097 cites W1986382801 @default.
• W2200599097 cites W1997459531 @default.
• W2200599097 cites W2027649047 @default.
• W2200599097 cites W2043219973 @default.
• W2200599097 cites W2047670537 @default.
• W2200599097 cites W2064337582 @default.
• W2200599097 cites W2068523052 @default.
• W2200599097 cites W2078389420 @default.
• W2200599097 cites W2080969265 @default.
• W2200599097 cites W2097806611 @default.
• W2200599097 cites W2101562875 @default.
• W2200599097 cites W2102116016 @default.
• W2200599097 cites W2102804476 @default.
• W2200599097 cites W2103257412 @default.
• W2200599097 cites W2145118120 @default.
• W2200599097 cites W2169013609 @default.
• W2200599097 cites W2170552969 @default.
• W2200599097 cites W2198445281 @default.
• W2200599097 cites W2590086644 @default.
• W2200599097 cites W3081492902 @default.
• W2200599097 doi "https://doi.org/10.1186/s12952-015-0037-5" @default.
• W2200599097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4641378" @default.
• W2200599097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26555878" @default.
• W2200599097 hasPublicationYear "2015" @default.
• W2200599097 type Work @default.
• W2200599097 sameAs 2200599097 @default.
• W2200599097 citedByCount "2" @default.
• W2200599097 countsByYear W22005990972020 @default.
• W2200599097 countsByYear W22005990972021 @default.
• W2200599097 crossrefType "journal-article" @default.
• W2200599097 hasAuthorship W2200599097A5001456598 @default.
• W2200599097 hasAuthorship W2200599097A5005874703 @default.
• W2200599097 hasAuthorship W2200599097A5010120065 @default.
• W2200599097 hasAuthorship W2200599097A5038456224 @default.
• W2200599097 hasAuthorship W2200599097A5047019507 @default.
• W2200599097 hasAuthorship W2200599097A5047763206 @default.
• W2200599097 hasAuthorship W2200599097A5065732872 @default.
• W2200599097 hasAuthorship W2200599097A5068223483 @default.
• W2200599097 hasAuthorship W2200599097A5073523132 @default.
• W2200599097 hasAuthorship W2200599097A5076354847 @default.
• W2200599097 hasAuthorship W2200599097A5084236822 @default.
• W2200599097 hasAuthorship W2200599097A5090993023 @default.
• W2200599097 hasBestOaLocation W22005990971 @default.
• W2200599097 hasConcept C121608353 @default.
• W2200599097 hasConcept C126322002 @default.
• W2200599097 hasConcept C143998085 @default.
• W2200599097 hasConcept C144301174 @default.
• W2200599097 hasConcept C167135981 @default.
• W2200599097 hasConcept C2776694085 @default.
• W2200599097 hasConcept C2776907518 @default.
• W2200599097 hasConcept C2780352672 @default.
• W2200599097 hasConcept C2911057145 @default.
• W2200599097 hasConcept C3019882237 @default.
• W2200599097 hasConcept C38180746 @default.
• W2200599097 hasConcept C71924100 @default.
• W2200599097 hasConcept C72563966 @default.
• W2200599097 hasConceptScore W2200599097C121608353 @default.
• W2200599097 hasConceptScore W2200599097C126322002 @default.
• W2200599097 hasConceptScore W2200599097C143998085 @default.
• W2200599097 hasConceptScore W2200599097C144301174 @default.
• W2200599097 hasConceptScore W2200599097C167135981 @default.
• W2200599097 hasConceptScore W2200599097C2776694085 @default.
• W2200599097 hasConceptScore W2200599097C2776907518 @default.
• W2200599097 hasConceptScore W2200599097C2780352672 @default.
• W2200599097 hasConceptScore W2200599097C2911057145 @default.
• W2200599097 hasConceptScore W2200599097C3019882237 @default.
• W2200599097 hasConceptScore W2200599097C38180746 @default.
• W2200599097 hasConceptScore W2200599097C71924100 @default.
• W2200599097 hasConceptScore W2200599097C72563966 @default.
• W2200599097 hasIssue "1" @default.
• W2200599097 hasLocation W22005990971 @default.
• W2200599097 hasLocation W22005990972 @default.
• W2200599097 hasLocation W22005990973 @default.
• W2200599097 hasLocation W22005990974 @default.
• W2200599097 hasLocation W22005990975 @default.
• W2200599097 hasLocation W22005990976 @default.
• W2200599097 hasLocation W22005990977 @default.
• W2200599097 hasOpenAccess W2200599097 @default.

• next