FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2200628332> ?p ?o ?g. }

• W2200628332 endingPage "850" @default.
• W2200628332 startingPage "843" @default.
• W2200628332 abstract "The hepatic cell death induced by acetaminophen (APAP) is closely related to cellular adenosine triphosphate (ATP) depletion, which is mainly caused by mitochondrial dysfunction. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of low energy status. AMPK regulates metabolic homeostasis by stimulating catabolic metabolism and suppressing anabolic pathways to increase cellular energy levels. We found that the decrease in active phosphorylation of AMPK in response to APAP correlates with decreased ATP levels, in vivo. Therefore, we hypothesized that the enhanced production of ATP via AMPK stimulation can lead to amelioration of APAP-induced liver failure. A769662, an allosteric activator of AMPK, produced a strong synergistic effect on AMPK Thr172 phosphorylation with APAP in primary hepatocytes and liver tissue. Interestingly, activation of AMPK by A769662 ameliorated the APAP-induced hepatotoxicity in C57BL/6N mice treated with APAP at a dose of 400 mg/kg intraperitoneally. However, mice treated with APAP alone developed massive centrilobular necrosis, and APAP increased their serum alanine aminotransferase and aspartate aminotransferase levels. Furthermore, A769662 administration prevented the loss of intracellular ATP without interfering with the APAP-mediated reduction of mitochondrial dysfunction. In contrast, inhibition of glycolysis by 2-deoxy-glucose eliminated the beneficial effects of A769662 on APAP-mediated liver injury. In conclusion, A769662 can effectively protect mice against APAP-induced liver injury through ATP synthesis by anaerobic glycolysis. Furthermore, stimulation of AMPK may have potential therapeutic application for APAP overdose." @default.
• W2200628332 created "2016-06-24" @default.
• W2200628332 creator A5001141603 @default.
• W2200628332 creator A5009178599 @default.
• W2200628332 creator A5011687488 @default.
• W2200628332 creator A5022331692 @default.
• W2200628332 creator A5068459756 @default.
• W2200628332 creator A5089385842 @default.
• W2200628332 date "2015-10-02" @default.
• W2200628332 modified "2023-10-18" @default.
• W2200628332 title "Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury" @default.
• W2200628332 cites W1576016712 @default.
• W2200628332 cites W1966833070 @default.
• W2200628332 cites W1967684747 @default.
• W2200628332 cites W1968881729 @default.
• W2200628332 cites W1972877540 @default.
• W2200628332 cites W1982584241 @default.
• W2200628332 cites W1988848089 @default.
• W2200628332 cites W1990233281 @default.
• W2200628332 cites W1997878364 @default.
• W2200628332 cites W2008351257 @default.
• W2200628332 cites W2064633971 @default.
• W2200628332 cites W2067816697 @default.
• W2200628332 cites W2067855744 @default.
• W2200628332 cites W2079350327 @default.
• W2200628332 cites W2079580613 @default.
• W2200628332 cites W2080680563 @default.
• W2200628332 cites W2084888282 @default.
• W2200628332 cites W2085558309 @default.
• W2200628332 cites W2085567056 @default.
• W2200628332 cites W2096979086 @default.
• W2200628332 cites W2097363242 @default.
• W2200628332 cites W2107101475 @default.
• W2200628332 cites W2108151355 @default.
• W2200628332 cites W2149687359 @default.
• W2200628332 cites W2150551377 @default.
• W2200628332 cites W2159518189 @default.
• W2200628332 cites W2161109243 @default.
• W2200628332 cites W2163790438 @default.
• W2200628332 cites W2166184359 @default.
• W2200628332 cites W2180542969 @default.
• W2200628332 cites W2419237336 @default.
• W2200628332 doi "https://doi.org/10.14348/molcells.2015.0072" @default.
• W2200628332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4625065" @default.
• W2200628332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26434492" @default.
• W2200628332 hasPublicationYear "2015" @default.
• W2200628332 type Work @default.
• W2200628332 sameAs 2200628332 @default.
• W2200628332 citedByCount "14" @default.
• W2200628332 countsByYear W22006283322017 @default.
• W2200628332 countsByYear W22006283322018 @default.
• W2200628332 countsByYear W22006283322019 @default.
• W2200628332 countsByYear W22006283322020 @default.
• W2200628332 countsByYear W22006283322021 @default.
• W2200628332 countsByYear W22006283322022 @default.
• W2200628332 countsByYear W22006283322023 @default.
• W2200628332 crossrefType "journal-article" @default.
• W2200628332 hasAuthorship W2200628332A5001141603 @default.
• W2200628332 hasAuthorship W2200628332A5009178599 @default.
• W2200628332 hasAuthorship W2200628332A5011687488 @default.
• W2200628332 hasAuthorship W2200628332A5022331692 @default.
• W2200628332 hasAuthorship W2200628332A5068459756 @default.
• W2200628332 hasAuthorship W2200628332A5089385842 @default.
• W2200628332 hasBestOaLocation W22006283321 @default.
• W2200628332 hasConcept C184235292 @default.
• W2200628332 hasConcept C185592680 @default.
• W2200628332 hasConcept C2776991684 @default.
• W2200628332 hasConcept C2778722691 @default.
• W2200628332 hasConcept C2779564974 @default.
• W2200628332 hasConcept C2779876172 @default.
• W2200628332 hasConcept C2780876210 @default.
• W2200628332 hasConcept C34628245 @default.
• W2200628332 hasConcept C55493867 @default.
• W2200628332 hasConcept C71924100 @default.
• W2200628332 hasConcept C86803240 @default.
• W2200628332 hasConcept C95444343 @default.
• W2200628332 hasConcept C97029542 @default.
• W2200628332 hasConcept C98274493 @default.
• W2200628332 hasConceptScore W2200628332C184235292 @default.
• W2200628332 hasConceptScore W2200628332C185592680 @default.
• W2200628332 hasConceptScore W2200628332C2776991684 @default.
• W2200628332 hasConceptScore W2200628332C2778722691 @default.
• W2200628332 hasConceptScore W2200628332C2779564974 @default.
• W2200628332 hasConceptScore W2200628332C2779876172 @default.
• W2200628332 hasConceptScore W2200628332C2780876210 @default.
• W2200628332 hasConceptScore W2200628332C34628245 @default.
• W2200628332 hasConceptScore W2200628332C55493867 @default.
• W2200628332 hasConceptScore W2200628332C71924100 @default.
• W2200628332 hasConceptScore W2200628332C86803240 @default.
• W2200628332 hasConceptScore W2200628332C95444343 @default.
• W2200628332 hasConceptScore W2200628332C97029542 @default.
• W2200628332 hasConceptScore W2200628332C98274493 @default.
• W2200628332 hasIssue "10" @default.
• W2200628332 hasLocation W22006283321 @default.
• W2200628332 hasLocation W22006283322 @default.
• W2200628332 hasLocation W22006283323 @default.
• W2200628332 hasOpenAccess W2200628332 @default.
• W2200628332 hasPrimaryLocation W22006283321 @default.

• next