FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2200702433> ?p ?o ?g. }

• W2200702433 endingPage "8105" @default.
• W2200702433 startingPage "8097" @default.
• W2200702433 abstract "Secreted phospholipases A2 (sPLA2) are suggested to play an important role in inflammation and tumorigenesis. Different mechanisms of epigenetic regulation are involved in the control of group IIA, III and X sPLA2s expression in cancer cells, but group V sPLA2 (GV-PLA2) in this respect has not been studied. Here, we demonstrate the role of epigenetic mechanisms in regulation of GV-PLA2 expression in different cell lines originating from leukaemia and solid cancers. In blood leukocytes from leukaemic patients, levels of GV-PLA2 transcripts were significantly lower in comparison to those from healthy individuals. Similarly, in DU-145 and PC-3 prostate and CAL-51 and MCF-7 mammary cancer cell lines, levels of GV-PLA2 transcripts were significantly lower in relation to those found in normal epithelial cells of prostate or mammary. By sequencing and methylation-specific high-resolution melting (MS-HRM) analyses of bisulphite-modified DNA, distinct CpG sites in the GV-PLA2 promoter region were identified that were differentially methylated in cancer cells in comparison to normal epithelial and endothelial cells. Spearman rank order analysis revealed a significant negative correlation between the methylation degree and the cellular expression of GV-PLA2 (r = −0.697; p = 0.01). The effects of demethylating agent (5-aza-2′-deoxycytidine) and histone deacetylase inhibitor (trichostatin A) on GV-PLA2 transcription in the analysed cells confirmed the importance of DNA methylation and histone modification in the regulation of the GV-PLA2 gene expression in leukaemic, prostate and mammary cancer cell lines. The exposure of tumour cells to human recombinant GV-PLA2 resulted in a reduced colony forming activity of MCF-7, HepG2 and PC-3 cells, but not of DU-145 cells suggesting a cell-type-dependent effect of GV-PLA2 on cell growth. In conclusion, our results suggest that epigenetic mechanisms such as DNA methylation and histone modification play an important role in downregulation of GV-PLA2 expression in cancer cells." @default.
• W2200702433 created "2016-06-24" @default.
• W2200702433 creator A5037427703 @default.
• W2200702433 creator A5047480914 @default.
• W2200702433 creator A5049638521 @default.
• W2200702433 creator A5059274436 @default.
• W2200702433 creator A5061073943 @default.
• W2200702433 creator A5080715229 @default.
• W2200702433 creator A5083812244 @default.
• W2200702433 date "2015-12-29" @default.
• W2200702433 modified "2023-10-16" @default.
• W2200702433 title "Epigenetic control of group V phospholipase A2 expression in human malignant cells" @default.
• W2200702433 cites W1524698046 @default.
• W2200702433 cites W1807832669 @default.
• W2200702433 cites W1882946118 @default.
• W2200702433 cites W1960586600 @default.
• W2200702433 cites W1967064280 @default.
• W2200702433 cites W1967170457 @default.
• W2200702433 cites W1967936833 @default.
• W2200702433 cites W1992860129 @default.
• W2200702433 cites W1994921380 @default.
• W2200702433 cites W2001991598 @default.
• W2200702433 cites W2006889116 @default.
• W2200702433 cites W2007109180 @default.
• W2200702433 cites W2009543111 @default.
• W2200702433 cites W2010587730 @default.
• W2200702433 cites W202696208 @default.
• W2200702433 cites W2027387500 @default.
• W2200702433 cites W2032063742 @default.
• W2200702433 cites W2037814757 @default.
• W2200702433 cites W2040257851 @default.
• W2200702433 cites W2044066446 @default.
• W2200702433 cites W2052419474 @default.
• W2200702433 cites W2059163718 @default.
• W2200702433 cites W2065522570 @default.
• W2200702433 cites W2073255984 @default.
• W2200702433 cites W2075363163 @default.
• W2200702433 cites W2078624782 @default.
• W2200702433 cites W2082668371 @default.
• W2200702433 cites W2084953042 @default.
• W2200702433 cites W2087157923 @default.
• W2200702433 cites W2088049958 @default.
• W2200702433 cites W2094408741 @default.
• W2200702433 cites W2115345848 @default.
• W2200702433 cites W2118278569 @default.
• W2200702433 cites W2130178468 @default.
• W2200702433 cites W2134146326 @default.
• W2200702433 cites W2139122477 @default.
• W2200702433 cites W2140182017 @default.
• W2200702433 cites W2143746442 @default.
• W2200702433 cites W2145305890 @default.
• W2200702433 cites W2164696627 @default.
• W2200702433 cites W2165200182 @default.
• W2200702433 cites W2167935048 @default.
• W2200702433 cites W2309659689 @default.
• W2200702433 cites W2331227932 @default.
• W2200702433 cites W2413139547 @default.
• W2200702433 cites W49838752 @default.
• W2200702433 doi "https://doi.org/10.1007/s13277-015-4670-x" @default.
• W2200702433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26715269" @default.
• W2200702433 hasPublicationYear "2015" @default.
• W2200702433 type Work @default.
• W2200702433 sameAs 2200702433 @default.
• W2200702433 citedByCount "10" @default.
• W2200702433 countsByYear W22007024332017 @default.
• W2200702433 countsByYear W22007024332018 @default.
• W2200702433 countsByYear W22007024332019 @default.
• W2200702433 countsByYear W22007024332023 @default.
• W2200702433 crossrefType "journal-article" @default.
• W2200702433 hasAuthorship W2200702433A5037427703 @default.
• W2200702433 hasAuthorship W2200702433A5047480914 @default.
• W2200702433 hasAuthorship W2200702433A5049638521 @default.
• W2200702433 hasAuthorship W2200702433A5059274436 @default.
• W2200702433 hasAuthorship W2200702433A5061073943 @default.
• W2200702433 hasAuthorship W2200702433A5080715229 @default.
• W2200702433 hasAuthorship W2200702433A5083812244 @default.
• W2200702433 hasConcept C104317684 @default.
• W2200702433 hasConcept C121608353 @default.
• W2200702433 hasConcept C140173407 @default.
• W2200702433 hasConcept C150194340 @default.
• W2200702433 hasConcept C153911025 @default.
• W2200702433 hasConcept C190727270 @default.
• W2200702433 hasConcept C2776202225 @default.
• W2200702433 hasConcept C2777865847 @default.
• W2200702433 hasConcept C2778305200 @default.
• W2200702433 hasConcept C2779277951 @default.
• W2200702433 hasConcept C2780192828 @default.
• W2200702433 hasConcept C33288867 @default.
• W2200702433 hasConcept C41091548 @default.
• W2200702433 hasConcept C502942594 @default.
• W2200702433 hasConcept C54355233 @default.
• W2200702433 hasConcept C555283112 @default.
• W2200702433 hasConcept C64927066 @default.
• W2200702433 hasConcept C86803240 @default.
• W2200702433 hasConceptScore W2200702433C104317684 @default.
• W2200702433 hasConceptScore W2200702433C121608353 @default.
• W2200702433 hasConceptScore W2200702433C140173407 @default.
• W2200702433 hasConceptScore W2200702433C150194340 @default.

• next