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- W2200889199 abstract "Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) were the main enzymes catalyzing lipolysis in the white adipose tissue. Since the discovery of adipose triglyceride lipase (ATGL) in 2004, many studies were performed to investigate and characterize the actions of this lipase, as well as of other proteins and possible regulatory mechanisms involved, which reformulated the concept of lipolysis. Novel findings from these studies include the identification of lipolytic products as signaling molecules regulating important metabolic processes in many non-adipose tissues, unveiling a previously underestimated aspect of lipolysis. Thus, we present here an updated review of concepts and regulation of white adipocyte lipolysis with a special emphasis in its role in metabolism homeostasis and as a source of important signaling molecules." @default.
- W2200889199 created "2016-06-24" @default.
- W2200889199 creator A5026646624 @default.
- W2200889199 creator A5069144944 @default.
- W2200889199 date "2015-08-01" @default.
- W2200889199 modified "2023-10-14" @default.
- W2200889199 title "Lipolysis and lipases in white adipose tissue – An update" @default.
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- W2200889199 doi "https://doi.org/10.1590/2359-3997000000067" @default.
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