FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201011109> ?p ?o ?g. }

• W2201011109 abstract "The HTR2C gene encodes the 5-Hydroxytryptamine (serotonin) receptor 2C, G-protein-coupled protein which functions as a serotonin receptor. The HTR2C mRNA is subject to A-to-I RNA editing mediated by adenosine deaminases acting on RNA 1 and 2 (ADAR1 and ADAR2). In the current study we examined the molecular characteristics of the porcine HTR2C gene and determined the mRNA editing of the HTR2C transcript in different tissues. The A-to-I RNA editing of HTR2C was shown to be conserved in the porcine homologue with five nucleotides edited in exon 5. A differential editing was demonstrated with a high editing frequency in the frontal cortex, parietal cortex, occipital cortex, hypothalamus, brain stem and spinal cord and significantly lower in the cerebellum. No editing was seen in the liver and kidney. The porcine HTR2C gene was found to be exclusively expressed in brain tissues. The HTR2C gene was mapped to pig chromosome X. The methylation status of the HTR2C gene was examined in brain and liver by bisulfate sequencing and a high degree of methylation was found in the two tissues, at 89 and 72%, respectively. Our data describe differences in RNA editing in various regions of the porcine brain. The differences might reflect functional differences. Similarities between pigs and humans in differential RNA editing support the use of the pig as a model organism for the study of neurological diseases." @default.
• W2201011109 created "2016-06-24" @default.
• W2201011109 creator A5034041092 @default.
• W2201011109 creator A5063416414 @default.
• W2201011109 creator A5072169715 @default.
• W2201011109 creator A5090367243 @default.
• W2201011109 date "2016-02-01" @default.
• W2201011109 modified "2023-09-27" @default.
• W2201011109 title "Differential A-to-I RNA editing of the serotonin-2C receptor G-protein-coupled, HTR2C, in porcine brain tissues" @default.
• W2201011109 cites W1594015135 @default.
• W2201011109 cites W1758644208 @default.
• W2201011109 cites W1807088015 @default.
• W2201011109 cites W1975371972 @default.
• W2201011109 cites W1977622433 @default.
• W2201011109 cites W1984120803 @default.
• W2201011109 cites W1986847092 @default.
• W2201011109 cites W1991344879 @default.
• W2201011109 cites W1994901510 @default.
• W2201011109 cites W1999048656 @default.
• W2201011109 cites W2004621199 @default.
• W2201011109 cites W2011986959 @default.
• W2201011109 cites W2017196201 @default.
• W2201011109 cites W2017785620 @default.
• W2201011109 cites W2018778450 @default.
• W2201011109 cites W2023923807 @default.
• W2201011109 cites W2026204366 @default.
• W2201011109 cites W2027971128 @default.
• W2201011109 cites W2030851549 @default.
• W2201011109 cites W2039892245 @default.
• W2201011109 cites W2039920104 @default.
• W2201011109 cites W2039996052 @default.
• W2201011109 cites W2048108096 @default.
• W2201011109 cites W2049413234 @default.
• W2201011109 cites W2050184180 @default.
• W2201011109 cites W2050191240 @default.
• W2201011109 cites W2058011091 @default.
• W2201011109 cites W2060005731 @default.
• W2201011109 cites W2068275172 @default.
• W2201011109 cites W2070280958 @default.
• W2201011109 cites W2073018558 @default.
• W2201011109 cites W2074202763 @default.
• W2201011109 cites W2074562954 @default.
• W2201011109 cites W2075644516 @default.
• W2201011109 cites W2083162388 @default.
• W2201011109 cites W2097065948 @default.
• W2201011109 cites W2097313424 @default.
• W2201011109 cites W2100163017 @default.
• W2201011109 cites W2105241705 @default.
• W2201011109 cites W2115809399 @default.
• W2201011109 cites W2116424257 @default.
• W2201011109 cites W2129977009 @default.
• W2201011109 cites W2133214868 @default.
• W2201011109 cites W2139013200 @default.
• W2201011109 cites W2141458291 @default.
• W2201011109 cites W2142386149 @default.
• W2201011109 cites W2143102422 @default.
• W2201011109 cites W2144634347 @default.
• W2201011109 cites W2153853866 @default.
• W2201011109 cites W2155105278 @default.
• W2201011109 cites W2156032876 @default.
• W2201011109 cites W2168597357 @default.
• W2201011109 cites W2168795031 @default.
• W2201011109 doi "https://doi.org/10.1016/j.biochi.2015.12.011" @default.
• W2201011109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26707647" @default.
• W2201011109 hasPublicationYear "2016" @default.
• W2201011109 type Work @default.
• W2201011109 sameAs 2201011109 @default.
• W2201011109 citedByCount "4" @default.
• W2201011109 countsByYear W22010111092016 @default.
• W2201011109 countsByYear W22010111092017 @default.
• W2201011109 countsByYear W22010111092020 @default.
• W2201011109 countsByYear W22010111092021 @default.
• W2201011109 crossrefType "journal-article" @default.
• W2201011109 hasAuthorship W2201011109A5034041092 @default.
• W2201011109 hasAuthorship W2201011109A5063416414 @default.
• W2201011109 hasAuthorship W2201011109A5072169715 @default.
• W2201011109 hasAuthorship W2201011109A5090367243 @default.
• W2201011109 hasConcept C104317684 @default.
• W2201011109 hasConcept C105580179 @default.
• W2201011109 hasConcept C153911025 @default.
• W2201011109 hasConcept C21786251 @default.
• W2201011109 hasConcept C36823959 @default.
• W2201011109 hasConcept C54355233 @default.
• W2201011109 hasConcept C67705224 @default.
• W2201011109 hasConcept C86803240 @default.
• W2201011109 hasConcept C95444343 @default.
• W2201011109 hasConceptScore W2201011109C104317684 @default.
• W2201011109 hasConceptScore W2201011109C105580179 @default.
• W2201011109 hasConceptScore W2201011109C153911025 @default.
• W2201011109 hasConceptScore W2201011109C21786251 @default.
• W2201011109 hasConceptScore W2201011109C36823959 @default.
• W2201011109 hasConceptScore W2201011109C54355233 @default.
• W2201011109 hasConceptScore W2201011109C67705224 @default.
• W2201011109 hasConceptScore W2201011109C86803240 @default.
• W2201011109 hasConceptScore W2201011109C95444343 @default.
• W2201011109 hasLocation W22010111091 @default.
• W2201011109 hasLocation W22010111092 @default.
• W2201011109 hasOpenAccess W2201011109 @default.
• W2201011109 hasPrimaryLocation W22010111091 @default.
• W2201011109 hasRelatedWork W1503164699 @default.

• next