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- W2201046697 abstract "Imatinib is a synthetic inhibitor of kinase-tyrosine used in the treatment of chronic myeloid leukemia (CML) and also is considered as the first-line drug for the treatment of this entity. The commonest side effects include: nausea, musculoskeletal pains, diarrhea, cutaneous Revista Cubana de Hematologia, Inmunologia y Hemoterapia. 2010; 26(1)223-227 http://scielo.sld.cu 224 eruption, fatigue and myelosuppression mainly at the expense of granulopoiesis line. A study was conducted in 43 adult patients (23 females and 20 males) presenting with CML pH in chronic phase, seen in the Hematology and Immunology Institute and in other Hematology services in our country. All cases showed resistance and intolerance to treatment with recombinant Alfa-Interferon (INFα) and Imatinib therapy (400 mg/day) from April, 2003 to July, 2008. The 48,8% of patients have not adverse reactions. The more frequent non-hematologic side effects include bone, muscular or both pain (23%), edema (23,3%); skin hypopigmentation (20,9%), and subcutaneous nodules (11,6%). In hematological reactions are included the drug-hemolytic anemia (14%) drug-immune anemia, drug immune thrombocytopenia (11,6%) and bicitopenia ( 9,3%)." @default.
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- W2201046697 date "2010-12-01" @default.
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- W2201046697 title "Adverse reactions to imatinib as second-line drug in patients with chronic myeloid leukemia" @default.
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