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- W22011098 abstract "Physiologically based airway aerosol deposition models provide a quantitative alternative to animal inhalation toxicology testing provided aerosol physicochemical properties are well defined, and sufficient airway anatomical and physiological data are available. Recent airway deposition models deal with the extrathoracic airways (nose, nasopharynx, mouth, oropharynx, and larynx) as a lumped compartment (1,2), or they avoid dealing with the anatomical complexities associated with these airways and use empirical deposition functions (3). These approaches, however, fail to the account for the effect dynamic changes in mucosal blood supply and upper airway geometry (particularly in the oral cavity) can have on regional airway (extrathoracic, tracheobronchial, and pulmonary airways) aerosol deposition. For example, if altering oral cavity geometry (moving the tongue) increases oropharyngeal deposition, then pulmonary deposition diminishes because particle numbers decline distal to the upper airway (4)." @default.
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- W22011098 date "1999-01-01" @default.
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- W22011098 title "The Role of Upper Airway Heat and Water Vapor Exchange in Hygroscopic Aerosol Deposition in the Human Airway" @default.
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- W22011098 doi "https://doi.org/10.1007/978-1-59259-718-5_6" @default.
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