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- W2201118575 abstract "Foot-and-mouth disease (FMD) is one of the most devastating diseases of livestock. The causative pathogen is an RNA virus, of which seven serotypes can be distinguished. Due to the variability of the virus, new strains occur regularly, posing severe challenges to vaccine manufacturers and authorities to adapt vaccination strategies in time. Because all cloven hoofed species can be infected, the virus spreads rapidly in susceptible populations, and is difficult to control. Cattle are particular susceptible, and require minute amounts of virus to become infected. Mortality is low, but morbidity can reach 100%. Significant advances have been made in the recent years, in particular, to reduce virus transmission, and in the characterisation, genotyping (with modern molecular biological tools), laboratory diagnosis, and epidemiology of the virus. Modern, purified vaccines allow Differentiating Infected from Vaccinated Animals with the so-called DIVA vaccines, in conjunction with enzyme-linked immunosorbent assays that detect antibodies against nonstructural proteins. Also outbreak control has improved, with better contingency plans, the organisation of simulation exercises, and, less fortunate, learning from several severe outbreaks in Europe and Asia. However, still areas exist where FMD is endemic, largely due to insufficient implementation of animal disease control measures, and difficult socioeconomic and geographic circumstances." @default.
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- W2201118575 date "2011-01-01" @default.
- W2201118575 modified "2023-09-25" @default.
- W2201118575 title "Diseases of Dairy Animals | Infectious Diseases: Foot-and-Mouth Disease" @default.
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- W2201118575 doi "https://doi.org/10.1016/b978-0-12-374407-4.00132-1" @default.
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