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- W2201178103 abstract "The infection of 1 day old SC Hyline chicks with avian leukosis virus (ALV) induces a bursal-dependent B cell lymphoma in approximately 50% of the population (Baba and Humphries 1984). This disease has provided a useful model for the examination of multistep neoplastic development (Purchase and Burmester 1978). Progression to terminal metastatic disease occurs only after 4 to 6 months of incubation and follows the appearance of distinct preneoplastic and neoplastic lesions (Cooper et al. 1968; Neiman et al. 1980). Both of these earlier stages are dependent upon the bursal microenvironment for their development. Progression from preneoplasia to neoplasia appears to be stochastic in nature (Baba and Humphries 1985). Examination of both the tumor and cell lines derived from the tumor has demonstrated that they synthesize and may secrete IgM (Cooper et al. 1974; Chen et al. 1983; Baba et al. 1985). Extensive analysis has demonstrated that ALV integration and formation of the provirus disrupts one allele of the c-myc locus (Hayward et al. 1981; Fung et al. 1981; Payne et al. 1982). This insertional mutagenesis results in elevated transcription of c-myc mRNA and appears to be responsible for the development of the preneoplastic lesion (Neiman et al. 1985; Thompson et al. 1987)." @default.
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- W2201178103 date "1988-01-01" @default.
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- W2201178103 title "The Development of Three Distinct Avian B Cell Lymphomas" @default.
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- W2201178103 doi "https://doi.org/10.1007/978-3-642-74006-0_9" @default.
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