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- W2201194739 endingPage "e0145197" @default.
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- W2201194739 abstract "Metastatic Ewing Sarcoma carries a poor prognosis, and novel therapeutics to prevent and treat metastatic disease are greatly needed. Recent evidence demonstrates that tumor-associated macrophages in Ewing Sarcoma are associated with more advanced disease. While some macrophage phenotypes (M1) exhibit anti-tumor activity, distinct phenotypes (M2) may contribute to malignant progression and metastasis. In this study, we show that M2 macrophages promote Ewing Sarcoma invasion and extravasation, pointing to a potential target of anti-metastatic therapy. CNI-1493 is a selective inhibitor of macrophage function and has shown to be safe in clinical trials as an anti-inflammatory agent. In a xenograft mouse model of metastatic Ewing Sarcoma, CNI-1493 treatment dramatically reduces metastatic tumor burden. Furthermore, metastases in treated animals have a less invasive morphology. We show in vitro that CNI-1493 decreases M2-stimulated Ewing Sarcoma tumor cell invasion and extravasation, offering a functional mechanism through which CNI-1493 attenuates metastasis. These data indicate that CNI-1493 may be a safe and effective adjuvant agent for the prevention and treatment of metastatic Ewing Sarcoma." @default.
- W2201194739 created "2016-06-24" @default.
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- W2201194739 date "2015-12-28" @default.
- W2201194739 modified "2023-10-16" @default.
- W2201194739 title "The Macrophage Inhibitor CNI-1493 Blocks Metastasis in a Mouse Model of Ewing Sarcoma through Inhibition of Extravasation" @default.
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- W2201194739 doi "https://doi.org/10.1371/journal.pone.0145197" @default.
- W2201194739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4692435" @default.
- W2201194739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26709919" @default.
- W2201194739 hasPublicationYear "2015" @default.
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