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- W2201202231 abstract "Obesity, defined as an excess fat mass, results from individual genetic and biological susceptibilities in response to the current weight-gain promoting environment. There is thus a synergistic relationship between genes and environment. Depending on the genes involved, different clinical situations are described: (1) monogenic obesity defined as rare and severe early-onset obesity associated with endocrine disorders, which are mainly due to autosomic recessive mutations in genes of the leptin-melanocortin axis – in some cases, such as leptin deficiency, specific treatments are efficient; (2) melanocortin 4 receptor-linked obesity characterized by the variable severity of obesity and the absence of additional phenotypes, which are involved in 2–3% of cases and eventually may benefit from new developed drugs (MC4R agonists); and (3) syndromic obesity where patients are clinically obese, and additionally distinguished by mental retardation, dysmorphic features, and organ-specific developmental abnormalities. No specific treatments are recommended except for hormonal substitution if necessary (growth hormone or gonadotrope deficiency)." @default.
- W2201202231 created "2016-06-24" @default.
- W2201202231 creator A5006876601 @default.
- W2201202231 creator A5011949930 @default.
- W2201202231 creator A5015767946 @default.
- W2201202231 creator A5038989175 @default.
- W2201202231 date "2016-01-01" @default.
- W2201202231 modified "2023-10-06" @default.
- W2201202231 title "Obesity" @default.
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