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- W2201202471 abstract "Abstract A group of N -phenylacetamide derivatives bearing five membered heterocyclic rings, pyrazole and 1,2,4-triazole, were synthesized to investigate their cholinesterase inhibitory activities. Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities were evaluated by using Ellman’s spectroscopic method. Results indicated that all of the compounds displayed moderate and selective AChE inhibitory activity and the most active compound was 2-(1 H -1,2,4-triazole-1-yl)- N -(3-methoxyphenyl)acetamide with an IC 50 value of 6.68 uM. Keywords: Alzheimer’s disease, pyrazole, 1,2,4-triazole, acetamide, cholinesterase inhibitory activity Ozet Pirazol ve 1,2,4-triazol tasiyan bir grup N -fenilasetamit turevi sentezlenmis ve kolinesteraz inhibitor aktiviteleri test edilmistir. Asetilkolinesteraz ve butirilkolinesteraz inhibitor aktiviteleri Ellman’in spektroskobik metoduna gore test edilmistir. Elde edilen sonuclar, tum bilesiklerin orta derecede ve secici asetilkolinesteraz inhibitor aktivite gosterdigini ortaya koymustur. Serideki en aktif bilesik ise 6.68 uM’lik IC 50 degeriyle 2-(1 H -1,2,4-triazol-1-il)- N -(3-metoksifenil)asetamit’tir." @default.
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- W2201202471 date "2015-10-01" @default.
- W2201202471 modified "2023-09-27" @default.
- W2201202471 title "Synthesis and cholinesterase inhibitory activity of some phenylacetamide derivatives bearing 1H-pyrazole and 1H-1,2,4-triazole" @default.
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- W2201202471 doi "https://doi.org/10.12991/mpj.2016202105828" @default.
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