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- W2201213085 abstract "Significance Decidual natural killer cells (dNK), the largest population of leukocytes at the maternal–fetal interface, have low cytotoxicity. They are believed to play a role in facilitating invasion of fetal HLA-G+ extravillous trophoblasts (EVT) into maternal tissues, a process essential for establishment of healthy pregnancies. dNK are low-cytotoxic while nonetheless containing cytotoxic granules and functioning in immunity to viral infections, illustrated here with human cytomegalo virus (HCMV). Interaction of dNK with EVT leads to acquisition of HLA-G by dNK (trogocytosis), followed by a cycle of internalization, degradation, and reacquisition of HLA-G. Cytokine activation facilitates HLA-G degradation and coincides with increased cytotoxicity by dNK. Thus, the cycle provides both for NK tolerance and antiviral immune function of dNK." @default.
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- W2201213085 date "2015-10-12" @default.
- W2201213085 modified "2023-10-17" @default.
- W2201213085 title "The HLA-G cycle provides for both NK tolerance and immunity at the maternal–fetal interface" @default.
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- W2201213085 doi "https://doi.org/10.1073/pnas.1517724112" @default.
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