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- W2201239534 endingPage "652" @default.
- W2201239534 startingPage "642" @default.
- W2201239534 abstract "The coordinated expression and activity of the iodothyronine deiodinases regulate thyroid hormone levels in hypothyroidism. Once heralded as the pathway underpinning adequate thyroid-hormone replacement therapy with levothyroxine, the role of these enzymes has come into question as they have been implicated in both an inability to normalize serum levels of tri-iodothyronine (T3) and the incomplete resolution of hypothyroid symptoms. These observations, some of which were validated in animal models of levothyroxine monotherapy, challenge the paradigm that tissue levels of T3 and thyroid-hormone signalling can be fully restored by administration of levothyroxine alone. The low serum levels of T3 observed among patients receiving levothyroxine monotherapy occur as a consequence of type 2 iodothyronine deiodinase (DIO2) in the hypothalamus being fairly insensitive to ubiquitination. In addition, residual symptoms of hypothyroidism have been linked to a prevalent polymorphism in the DIO2 gene that might be a risk factor for neurodegenerative disease. Here, we discuss how these novel findings underscore the clinical importance of iodothyronine deiodinases in hypothyroidism and how an improved understanding of these enzymes might translate to therapeutic advances in the care of millions of patients with this condition." @default.
- W2201239534 created "2016-06-24" @default.
- W2201239534 creator A5015835109 @default.
- W2201239534 creator A5026395401 @default.
- W2201239534 creator A5034024280 @default.
- W2201239534 creator A5083906656 @default.
- W2201239534 date "2015-09-29" @default.
- W2201239534 modified "2023-10-05" @default.
- W2201239534 title "Scope and limitations of iodothyronine deiodinases in hypothyroidism" @default.
- W2201239534 cites W1629453990 @default.
- W2201239534 cites W1747119434 @default.
- W2201239534 cites W1888479777 @default.
- W2201239534 cites W1900867665 @default.
- W2201239534 cites W1963784968 @default.
- W2201239534 cites W1964588432 @default.
- W2201239534 cites W1964976785 @default.
- W2201239534 cites W1965433050 @default.
- W2201239534 cites W1965529563 @default.
- W2201239534 cites W1968878341 @default.
- W2201239534 cites W1969176109 @default.
- W2201239534 cites W1975345061 @default.
- W2201239534 cites W1976707420 @default.
- W2201239534 cites W1978818320 @default.
- W2201239534 cites W1979030149 @default.
- W2201239534 cites W1979495452 @default.
- W2201239534 cites W1984620537 @default.
- W2201239534 cites W1986425038 @default.
- W2201239534 cites W1988377203 @default.
- W2201239534 cites W1988405671 @default.
- W2201239534 cites W1988806474 @default.
- W2201239534 cites W1989945628 @default.
- W2201239534 cites W1992073888 @default.
- W2201239534 cites W1992880394 @default.
- W2201239534 cites W1993618816 @default.
- W2201239534 cites W1996695469 @default.
- W2201239534 cites W1999031614 @default.
- W2201239534 cites W2002197081 @default.
- W2201239534 cites W2005744729 @default.
- W2201239534 cites W2006117703 @default.
- W2201239534 cites W2009604530 @default.
- W2201239534 cites W2011717087 @default.
- W2201239534 cites W2014871570 @default.
- W2201239534 cites W2015843695 @default.
- W2201239534 cites W2017632004 @default.
- W2201239534 cites W2021314292 @default.
- W2201239534 cites W2022349101 @default.
- W2201239534 cites W2022642300 @default.
- W2201239534 cites W2023134890 @default.
- W2201239534 cites W2023817599 @default.
- W2201239534 cites W2024116370 @default.
- W2201239534 cites W2024314748 @default.
- W2201239534 cites W2024675721 @default.
- W2201239534 cites W2027530011 @default.
- W2201239534 cites W2029466876 @default.
- W2201239534 cites W2030192432 @default.
- W2201239534 cites W2033265097 @default.
- W2201239534 cites W2033553696 @default.
- W2201239534 cites W2033638549 @default.
- W2201239534 cites W2034778853 @default.
- W2201239534 cites W2034991780 @default.
- W2201239534 cites W2035160565 @default.
- W2201239534 cites W2035564025 @default.
- W2201239534 cites W2038334005 @default.
- W2201239534 cites W2038424092 @default.
- W2201239534 cites W2041785016 @default.
- W2201239534 cites W2042163502 @default.
- W2201239534 cites W2045087560 @default.
- W2201239534 cites W2048245477 @default.
- W2201239534 cites W2055205764 @default.
- W2201239534 cites W2057808752 @default.
- W2201239534 cites W2059487357 @default.
- W2201239534 cites W2060405471 @default.
- W2201239534 cites W2061371885 @default.
- W2201239534 cites W2061863452 @default.
- W2201239534 cites W2065359672 @default.
- W2201239534 cites W2068281930 @default.
- W2201239534 cites W2068672685 @default.
- W2201239534 cites W2073915823 @default.
- W2201239534 cites W2075650590 @default.
- W2201239534 cites W2075732656 @default.
- W2201239534 cites W2080949697 @default.
- W2201239534 cites W2083714907 @default.
- W2201239534 cites W2084032963 @default.
- W2201239534 cites W2088262036 @default.
- W2201239534 cites W2088458025 @default.
- W2201239534 cites W2089891688 @default.
- W2201239534 cites W2090365086 @default.
- W2201239534 cites W2090755454 @default.
- W2201239534 cites W2091221706 @default.
- W2201239534 cites W2091900683 @default.
- W2201239534 cites W2097440306 @default.
- W2201239534 cites W2097615700 @default.
- W2201239534 cites W2098446121 @default.
- W2201239534 cites W2100049277 @default.
- W2201239534 cites W2101123075 @default.
- W2201239534 cites W2104878795 @default.
- W2201239534 cites W2104910867 @default.
- W2201239534 cites W2105299400 @default.