Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201269316> ?p ?o ?g. }
- W2201269316 endingPage "299" @default.
- W2201269316 startingPage "277" @default.
- W2201269316 abstract "Peptides and proteins have potent effects on the brain after their peripheral administration, suggesting that they may be good substrates for the development of CNS therapeutics. Major hurdles to such development include their relation to the blood–brain barrier (BBB) and poor pharmacokinetics. Some peptides cross the BBB by transendothelial diffusion and others cross in the blood-to-brain direction by saturable transporters. Some regulatory proteins are also transported across the BBB and antibodies can enter the CNS via the extracellular pathways. Glycoproteins and some antibody fragments can be taken up and cross the BBB by mechanisms related to adsorptive endocytosis/transcytosis. Many peptides and proteins are transported out of the CNS by saturable efflux systems and enzymatic activity in the blood, CNS, or BBB are substantial barriers to others. Both influx and efflux transporters are altered by various substances and in disease states. Strategies that manipulate these interactions between the BBB and peptides and proteins provide many opportunities for the development of therapeutics. Such strategies include increasing transendothelial diffusion of small peptides, upregulation of saturable influx transporters with allosteric regulators and other posttranslational means, use of vectors and other Trojan horse strategies, inhibition of efflux transporters including with antisense molecules, and improvement in pharmacokinetic parameters to overcome short half-lives, tissue sequestration, and enzymatic degradation." @default.
- W2201269316 created "2016-06-24" @default.
- W2201269316 creator A5039789938 @default.
- W2201269316 creator A5054959155 @default.
- W2201269316 date "2014-01-01" @default.
- W2201269316 modified "2023-10-17" @default.
- W2201269316 title "Delivery of Therapeutic Peptides and Proteins to the CNS" @default.
- W2201269316 cites W1505683203 @default.
- W2201269316 cites W1541446070 @default.
- W2201269316 cites W1594197304 @default.
- W2201269316 cites W162320534 @default.
- W2201269316 cites W1900516676 @default.
- W2201269316 cites W1909683981 @default.
- W2201269316 cites W19630745 @default.
- W2201269316 cites W1964314802 @default.
- W2201269316 cites W1965628077 @default.
- W2201269316 cites W1966286941 @default.
- W2201269316 cites W1967908989 @default.
- W2201269316 cites W1968214306 @default.
- W2201269316 cites W1980260989 @default.
- W2201269316 cites W1983694234 @default.
- W2201269316 cites W1985703181 @default.
- W2201269316 cites W1989060870 @default.
- W2201269316 cites W1989561275 @default.
- W2201269316 cites W1991849045 @default.
- W2201269316 cites W1992758695 @default.
- W2201269316 cites W1994125288 @default.
- W2201269316 cites W1994452576 @default.
- W2201269316 cites W1994462973 @default.
- W2201269316 cites W1995123320 @default.
- W2201269316 cites W1996574563 @default.
- W2201269316 cites W1996719014 @default.
- W2201269316 cites W1999061307 @default.
- W2201269316 cites W2000285669 @default.
- W2201269316 cites W2000329187 @default.
- W2201269316 cites W2002358623 @default.
- W2201269316 cites W2003736464 @default.
- W2201269316 cites W2004556707 @default.
- W2201269316 cites W2010856791 @default.
- W2201269316 cites W2011356699 @default.
- W2201269316 cites W2013280216 @default.
- W2201269316 cites W2015541518 @default.
- W2201269316 cites W2021255508 @default.
- W2201269316 cites W2022195343 @default.
- W2201269316 cites W2024089864 @default.
- W2201269316 cites W2025061302 @default.
- W2201269316 cites W2026422955 @default.
- W2201269316 cites W2027655401 @default.
- W2201269316 cites W2028267884 @default.
- W2201269316 cites W2028842702 @default.
- W2201269316 cites W2030427429 @default.
- W2201269316 cites W2031150193 @default.
- W2201269316 cites W2033784609 @default.
- W2201269316 cites W2033912043 @default.
- W2201269316 cites W2042526601 @default.
- W2201269316 cites W2043458888 @default.
- W2201269316 cites W2045320365 @default.
- W2201269316 cites W2045401856 @default.
- W2201269316 cites W2047607172 @default.
- W2201269316 cites W2047866696 @default.
- W2201269316 cites W2048428129 @default.
- W2201269316 cites W2050991123 @default.
- W2201269316 cites W2052465579 @default.
- W2201269316 cites W2055738732 @default.
- W2201269316 cites W2057028172 @default.
- W2201269316 cites W2059111801 @default.
- W2201269316 cites W2066120788 @default.
- W2201269316 cites W2066912376 @default.
- W2201269316 cites W2067282464 @default.
- W2201269316 cites W2067733328 @default.
- W2201269316 cites W2069179199 @default.
- W2201269316 cites W2072434736 @default.
- W2201269316 cites W2076385318 @default.
- W2201269316 cites W2077851646 @default.
- W2201269316 cites W2081868313 @default.
- W2201269316 cites W2084304466 @default.
- W2201269316 cites W2089822614 @default.
- W2201269316 cites W2090097368 @default.
- W2201269316 cites W2095381691 @default.
- W2201269316 cites W2095473686 @default.
- W2201269316 cites W2096996795 @default.
- W2201269316 cites W2101099825 @default.
- W2201269316 cites W2106437384 @default.
- W2201269316 cites W2107325549 @default.
- W2201269316 cites W2109699895 @default.
- W2201269316 cites W2112893277 @default.
- W2201269316 cites W2118857937 @default.
- W2201269316 cites W2125136428 @default.
- W2201269316 cites W2126744429 @default.
- W2201269316 cites W2128823466 @default.
- W2201269316 cites W2131337332 @default.
- W2201269316 cites W2132766192 @default.
- W2201269316 cites W2147018428 @default.
- W2201269316 cites W2147555925 @default.
- W2201269316 cites W2149162020 @default.
- W2201269316 cites W2153192347 @default.
- W2201269316 cites W2154091330 @default.
- W2201269316 cites W2162676548 @default.