Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201372986> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2201372986 endingPage "488" @default.
- W2201372986 startingPage "483" @default.
- W2201372986 abstract "Objective: To investigate the effects of up-regulation of integrin β1 on tumor cell proliferation and tumor growth of non-small cell lung cancer (NSCLC) inhibited by gefitinib, a epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). Methods: Three NSCLC cell lines including PC9, PC9/PCD (transfected with empty plasmid pcDNA 3.1) and PC9/D6 (transfected with integrin β1-expressed plasmid) were treated with 0.5 μmol/L gefitinib. The cell proliferation was detected by MTT assay. The graft tumors from the three cell lines in nude mice were established, respectively, and then they were randomly received 3 mg/kg gefitinib or 1% Tween-80. The tumor growth was observed and the growth curve was drawn. The tumor weight was recorded and the tumor growth inhibition rate was calculated. The expressions of integrin β1, EGFR and pEGFR in tumor tissues were examined by immunohistochemistry. Results: The proliferation rate of PC9/D6 cells transfected with integrin β1 was significantly higher than those of PC9/PCD and PC9 cells (P＜0.05). The graft tumor growth inhibition rates were 61.38%, 93.54% and 95.16% in the PC9/D6, PC9/PCD and PC9 groups, respectively; the differences between the PC9/D6 group and the PC9/PCD and PC9 groups were significant (both P＜0.01). The expression of pEGFR was decreased in the three graft tumor groups after treating with gefitinib; however, the expression levels of pEGFR and integrin β1 in PC9/D6 group were significantly higher than those in the PC9/PCD and PC9 groups (P＜0.01). There was no obvious difference in the expression level of EGFR among the three groups. Conclusion: The up-regulation of integrin β1 may decrease the sensitivity to gefitinib in NSCLC in vitro and in vivo. Therefore, integrin β1 may be implicated in drug resistance to EGFR-TKIs via a new mechanism. DOI:10.3781/j.issn.1000-7431.2011.06.002" @default.
- W2201372986 created "2016-06-24" @default.
- W2201372986 creator A5032473973 @default.
- W2201372986 creator A5064098081 @default.
- W2201372986 creator A5077156702 @default.
- W2201372986 date "2011-06-25" @default.
- W2201372986 modified "2023-09-25" @default.
- W2201372986 title "The role of up-regulation of integrin β1 in resistance to gefitinib in non-small cell lung cancer" @default.
- W2201372986 hasPublicationYear "2011" @default.
- W2201372986 type Work @default.
- W2201372986 sameAs 2201372986 @default.
- W2201372986 citedByCount "0" @default.
- W2201372986 crossrefType "journal-article" @default.
- W2201372986 hasAuthorship W2201372986A5032473973 @default.
- W2201372986 hasAuthorship W2201372986A5064098081 @default.
- W2201372986 hasAuthorship W2201372986A5077156702 @default.
- W2201372986 hasConcept C121608353 @default.
- W2201372986 hasConcept C126322002 @default.
- W2201372986 hasConcept C1491633281 @default.
- W2201372986 hasConcept C170493617 @default.
- W2201372986 hasConcept C195687474 @default.
- W2201372986 hasConcept C2776256026 @default.
- W2201372986 hasConcept C2776362946 @default.
- W2201372986 hasConcept C2779438470 @default.
- W2201372986 hasConcept C2779707156 @default.
- W2201372986 hasConcept C2780580887 @default.
- W2201372986 hasConcept C502942594 @default.
- W2201372986 hasConcept C54009773 @default.
- W2201372986 hasConcept C54355233 @default.
- W2201372986 hasConcept C55493867 @default.
- W2201372986 hasConcept C62112901 @default.
- W2201372986 hasConcept C71924100 @default.
- W2201372986 hasConcept C81885089 @default.
- W2201372986 hasConcept C86803240 @default.
- W2201372986 hasConceptScore W2201372986C121608353 @default.
- W2201372986 hasConceptScore W2201372986C126322002 @default.
- W2201372986 hasConceptScore W2201372986C1491633281 @default.
- W2201372986 hasConceptScore W2201372986C170493617 @default.
- W2201372986 hasConceptScore W2201372986C195687474 @default.
- W2201372986 hasConceptScore W2201372986C2776256026 @default.
- W2201372986 hasConceptScore W2201372986C2776362946 @default.
- W2201372986 hasConceptScore W2201372986C2779438470 @default.
- W2201372986 hasConceptScore W2201372986C2779707156 @default.
- W2201372986 hasConceptScore W2201372986C2780580887 @default.
- W2201372986 hasConceptScore W2201372986C502942594 @default.
- W2201372986 hasConceptScore W2201372986C54009773 @default.
- W2201372986 hasConceptScore W2201372986C54355233 @default.
- W2201372986 hasConceptScore W2201372986C55493867 @default.
- W2201372986 hasConceptScore W2201372986C62112901 @default.
- W2201372986 hasConceptScore W2201372986C71924100 @default.
- W2201372986 hasConceptScore W2201372986C81885089 @default.
- W2201372986 hasConceptScore W2201372986C86803240 @default.
- W2201372986 hasIssue "6" @default.
- W2201372986 hasLocation W22013729861 @default.
- W2201372986 hasOpenAccess W2201372986 @default.
- W2201372986 hasPrimaryLocation W22013729861 @default.
- W2201372986 hasRelatedWork W2009287831 @default.
- W2201372986 hasRelatedWork W2033730876 @default.
- W2201372986 hasRelatedWork W2078647284 @default.
- W2201372986 hasRelatedWork W2131119309 @default.
- W2201372986 hasRelatedWork W2239700864 @default.
- W2201372986 hasRelatedWork W2268177726 @default.
- W2201372986 hasRelatedWork W2354344650 @default.
- W2201372986 hasRelatedWork W2359335011 @default.
- W2201372986 hasRelatedWork W2359505293 @default.
- W2201372986 hasRelatedWork W2360651816 @default.
- W2201372986 hasRelatedWork W2378234093 @default.
- W2201372986 hasRelatedWork W2378406360 @default.
- W2201372986 hasRelatedWork W2391045029 @default.
- W2201372986 hasRelatedWork W2438628248 @default.
- W2201372986 hasRelatedWork W2945821755 @default.
- W2201372986 hasRelatedWork W2966461747 @default.
- W2201372986 hasRelatedWork W2975193376 @default.
- W2201372986 hasRelatedWork W2978932460 @default.
- W2201372986 hasRelatedWork W3098516153 @default.
- W2201372986 hasRelatedWork W2119782525 @default.
- W2201372986 hasVolume "31" @default.
- W2201372986 isParatext "false" @default.
- W2201372986 isRetracted "false" @default.
- W2201372986 magId "2201372986" @default.
- W2201372986 workType "article" @default.