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- W2201375253 abstract "Treatment in vitro of nude mouse spleen prothymocytes with relatively low concentrations (1–50 ug/ml) of trypsin induce the Thy 1−- to Thy 1+ conversion. The effect of trypsin was inhibited by prior heating or by addition of soybean trypsin inhibitor. The maximal effect achieved by trypsin treatment, approximately 25% conversion of spleen cells from layer B of an albumin gradient into theta-positive cells, was equivalent to that obtained with thymic hormone preparation (TP-1) at 10 ng/ml. Maximal conversion required 120 min incubation with TP-1 or trypsin. We conclude that both trypsin and TP-1 act by perturbation of a membrane receptor which can send a signal initiating the differentiation process." @default.
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- W2201375253 date "1984-01-01" @default.
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- W2201375253 title "Differentiation of Prothymocytes Induced by Trypsin" @default.
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- W2201375253 doi "https://doi.org/10.3109/08820138409048665" @default.
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