Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201430178> ?p ?o ?g. }
- W2201430178 endingPage "1350" @default.
- W2201430178 startingPage "1342" @default.
- W2201430178 abstract "Elevated cerebrospinal fluid (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been implicated in schizophrenia and bipolar disorder. Here, we conducted a genome-wide association study based on CSF KYNA in bipolar disorder and found support for an association with a common variant within 1p21.3. After replication in an independent cohort, we linked this genetic variant-associated with reduced SNX7 expression-to positive psychotic symptoms and executive function deficits in bipolar disorder. A series of post-mortem brain tissue and in vitro experiments suggested SNX7 downregulation to result in a caspase-8-driven activation of interleukin-1β and a subsequent induction of the brain kynurenine pathway. The current study demonstrates the potential of using biomarkers in genetic studies of psychiatric disorders, and may help to identify novel drug targets in bipolar disorder." @default.
- W2201430178 created "2016-06-24" @default.
- W2201430178 creator A5009644444 @default.
- W2201430178 creator A5022810412 @default.
- W2201430178 creator A5023024313 @default.
- W2201430178 creator A5023206431 @default.
- W2201430178 creator A5028236928 @default.
- W2201430178 creator A5032620135 @default.
- W2201430178 creator A5043788145 @default.
- W2201430178 creator A5044998046 @default.
- W2201430178 creator A5045856839 @default.
- W2201430178 creator A5046450925 @default.
- W2201430178 creator A5046910847 @default.
- W2201430178 creator A5053574652 @default.
- W2201430178 creator A5055128103 @default.
- W2201430178 creator A5060982659 @default.
- W2201430178 creator A5061802355 @default.
- W2201430178 creator A5062214008 @default.
- W2201430178 creator A5065013242 @default.
- W2201430178 creator A5070016214 @default.
- W2201430178 creator A5070089176 @default.
- W2201430178 creator A5087309336 @default.
- W2201430178 date "2015-12-15" @default.
- W2201430178 modified "2023-10-17" @default.
- W2201430178 title "A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder" @default.
- W2201430178 cites W1560694149 @default.
- W2201430178 cites W1972698844 @default.
- W2201430178 cites W1984426948 @default.
- W2201430178 cites W1989568128 @default.
- W2201430178 cites W1997591291 @default.
- W2201430178 cites W2002403033 @default.
- W2201430178 cites W2007861303 @default.
- W2201430178 cites W2012177752 @default.
- W2201430178 cites W2014413253 @default.
- W2201430178 cites W2017661386 @default.
- W2201430178 cites W2019465651 @default.
- W2201430178 cites W2022138195 @default.
- W2201430178 cites W2022349991 @default.
- W2201430178 cites W2024737904 @default.
- W2201430178 cites W2028370746 @default.
- W2201430178 cites W2028884770 @default.
- W2201430178 cites W2030740270 @default.
- W2201430178 cites W2032537064 @default.
- W2201430178 cites W2035559498 @default.
- W2201430178 cites W2039364994 @default.
- W2201430178 cites W2042659370 @default.
- W2201430178 cites W2044699444 @default.
- W2201430178 cites W2045227722 @default.
- W2201430178 cites W2048545238 @default.
- W2201430178 cites W2050792638 @default.
- W2201430178 cites W2052373965 @default.
- W2201430178 cites W2053293102 @default.
- W2201430178 cites W2056547365 @default.
- W2201430178 cites W2058338914 @default.
- W2201430178 cites W2060050678 @default.
- W2201430178 cites W2067270513 @default.
- W2201430178 cites W2072102207 @default.
- W2201430178 cites W2077455126 @default.
- W2201430178 cites W2077609442 @default.
- W2201430178 cites W2093824352 @default.
- W2201430178 cites W2095920783 @default.
- W2201430178 cites W2097944074 @default.
- W2201430178 cites W2100454832 @default.
- W2201430178 cites W2104703976 @default.
- W2201430178 cites W2110837219 @default.
- W2201430178 cites W2117970703 @default.
- W2201430178 cites W2123580195 @default.
- W2201430178 cites W2126847397 @default.
- W2201430178 cites W2133436525 @default.
- W2201430178 cites W2137823415 @default.
- W2201430178 cites W2141677575 @default.
- W2201430178 cites W2143069306 @default.
- W2201430178 cites W2146738944 @default.
- W2201430178 cites W2166711199 @default.
- W2201430178 doi "https://doi.org/10.1038/mp.2015.186" @default.
- W2201430178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4990004" @default.
- W2201430178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26666201" @default.
- W2201430178 hasPublicationYear "2015" @default.
- W2201430178 type Work @default.
- W2201430178 sameAs 2201430178 @default.
- W2201430178 citedByCount "68" @default.
- W2201430178 countsByYear W22014301782016 @default.
- W2201430178 countsByYear W22014301782017 @default.
- W2201430178 countsByYear W22014301782018 @default.
- W2201430178 countsByYear W22014301782019 @default.
- W2201430178 countsByYear W22014301782020 @default.
- W2201430178 countsByYear W22014301782021 @default.
- W2201430178 countsByYear W22014301782022 @default.
- W2201430178 countsByYear W22014301782023 @default.
- W2201430178 crossrefType "journal-article" @default.
- W2201430178 hasAuthorship W2201430178A5009644444 @default.
- W2201430178 hasAuthorship W2201430178A5022810412 @default.
- W2201430178 hasAuthorship W2201430178A5023024313 @default.
- W2201430178 hasAuthorship W2201430178A5023206431 @default.
- W2201430178 hasAuthorship W2201430178A5028236928 @default.
- W2201430178 hasAuthorship W2201430178A5032620135 @default.
- W2201430178 hasAuthorship W2201430178A5043788145 @default.
- W2201430178 hasAuthorship W2201430178A5044998046 @default.