Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201460708> ?p ?o ?g. }
- W2201460708 endingPage "e0145322" @default.
- W2201460708 startingPage "e0145322" @default.
- W2201460708 abstract "Genomic technologies including microarrays and next-generation sequencing have enabled the generation of molecular signatures of prostate cancer. Lists of differentially expressed genes between malignant and non-malignant states are thought to be fertile sources of putative prostate cancer biomarkers. However such lists of differentially expressed genes can be highly variable for multiple reasons. As such, looking at differential expression in the context of gene sets and pathways has been more robust. Using next-generation genome sequencing data from The Cancer Genome Atlas, differential gene expression between age- and stage- matched human prostate tumors and non-malignant samples was assessed and used to craft a pathway signature of prostate cancer. Up- and down-regulated genes were assigned to pathways composed of curated groups of related genes from multiple databases. The significance of these pathways was then evaluated according to the number of differentially expressed genes found in the pathway and their position within the pathway using Gene Set Enrichment Analysis and Signaling Pathway Impact Analysis. The transforming growth factor-beta signaling and Ran regulation of mitotic spindle formation pathways were strongly associated with prostate cancer. Several other significant pathways confirm reported findings from microarray data that suggest actin cytoskeleton regulation, cell cycle, mitogen-activated protein kinase signaling, and calcium signaling are also altered in prostate cancer. Thus we have demonstrated feasibility of pathway analysis and identified an underexplored area (Ran) for investigation in prostate cancer pathogenesis." @default.
- W2201460708 created "2016-06-24" @default.
- W2201460708 creator A5000775605 @default.
- W2201460708 creator A5010970756 @default.
- W2201460708 creator A5018043846 @default.
- W2201460708 creator A5041873395 @default.
- W2201460708 date "2015-12-18" @default.
- W2201460708 modified "2023-10-16" @default.
- W2201460708 title "Differentially Expressed Genes and Signature Pathways of Human Prostate Cancer" @default.
- W2201460708 cites W1481680243 @default.
- W2201460708 cites W1493110208 @default.
- W2201460708 cites W1494055834 @default.
- W2201460708 cites W1517364118 @default.
- W2201460708 cites W1525585340 @default.
- W2201460708 cites W1529982641 @default.
- W2201460708 cites W1544054537 @default.
- W2201460708 cites W1553178519 @default.
- W2201460708 cites W1556655356 @default.
- W2201460708 cites W1571487648 @default.
- W2201460708 cites W1571917377 @default.
- W2201460708 cites W1592603695 @default.
- W2201460708 cites W1597339764 @default.
- W2201460708 cites W1598913124 @default.
- W2201460708 cites W1601826601 @default.
- W2201460708 cites W1614690294 @default.
- W2201460708 cites W1819383973 @default.
- W2201460708 cites W1878169898 @default.
- W2201460708 cites W1909751975 @default.
- W2201460708 cites W1935876923 @default.
- W2201460708 cites W1936449500 @default.
- W2201460708 cites W1963767618 @default.
- W2201460708 cites W1964636114 @default.
- W2201460708 cites W1966187746 @default.
- W2201460708 cites W1966559042 @default.
- W2201460708 cites W1966615054 @default.
- W2201460708 cites W1967410029 @default.
- W2201460708 cites W1967990571 @default.
- W2201460708 cites W1970786059 @default.
- W2201460708 cites W1972298018 @default.
- W2201460708 cites W1973564464 @default.
- W2201460708 cites W1974466704 @default.
- W2201460708 cites W1976148924 @default.
- W2201460708 cites W1977138354 @default.
- W2201460708 cites W1978656137 @default.
- W2201460708 cites W1980954186 @default.
- W2201460708 cites W1982519496 @default.
- W2201460708 cites W1982552468 @default.
- W2201460708 cites W1984100287 @default.
- W2201460708 cites W1984400774 @default.
- W2201460708 cites W1984539870 @default.
- W2201460708 cites W1986052421 @default.
- W2201460708 cites W1989989224 @default.
- W2201460708 cites W1991656527 @default.
- W2201460708 cites W1991829110 @default.
- W2201460708 cites W1992045522 @default.
- W2201460708 cites W1993527788 @default.
- W2201460708 cites W1994708043 @default.
- W2201460708 cites W1995194065 @default.
- W2201460708 cites W1997284260 @default.
- W2201460708 cites W1999081109 @default.
- W2201460708 cites W1999753349 @default.
- W2201460708 cites W2000056288 @default.
- W2201460708 cites W2002246796 @default.
- W2201460708 cites W2003605385 @default.
- W2201460708 cites W2005303835 @default.
- W2201460708 cites W2005472560 @default.
- W2201460708 cites W2005675626 @default.
- W2201460708 cites W2009017218 @default.
- W2201460708 cites W2009052021 @default.
- W2201460708 cites W2014058353 @default.
- W2201460708 cites W2014977510 @default.
- W2201460708 cites W2017828300 @default.
- W2201460708 cites W2022472106 @default.
- W2201460708 cites W2022731471 @default.
- W2201460708 cites W2025795030 @default.
- W2201460708 cites W2025937460 @default.
- W2201460708 cites W2028754906 @default.
- W2201460708 cites W2031687428 @default.
- W2201460708 cites W2032611510 @default.
- W2201460708 cites W2033584792 @default.
- W2201460708 cites W2033655686 @default.
- W2201460708 cites W2035210630 @default.
- W2201460708 cites W2036760739 @default.
- W2201460708 cites W2036902495 @default.
- W2201460708 cites W2042493664 @default.
- W2201460708 cites W2043672855 @default.
- W2201460708 cites W2046510888 @default.
- W2201460708 cites W2048603557 @default.
- W2201460708 cites W2049775573 @default.
- W2201460708 cites W2053556067 @default.
- W2201460708 cites W2054582734 @default.
- W2201460708 cites W2055744107 @default.
- W2201460708 cites W2060672363 @default.
- W2201460708 cites W2064042294 @default.
- W2201460708 cites W2065891752 @default.
- W2201460708 cites W2070359341 @default.
- W2201460708 cites W2070998226 @default.
- W2201460708 cites W2071037802 @default.