Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201477891> ?p ?o ?g. }
- W2201477891 abstract "Increasing sinus pneumatization and the accompanying alveolar bone resorption complicate dental implant placement. This problem can be overcome today by raising the maxillary sinus floor with graft materials. Bisphosphonates are commonly used to accelerate the recovery of the graft materials and to prevent resorption.The purpose of this study is to investigate whether systemic administration of a bisphosphonate (alendronate) would improve new bone formation and reduce fibrous tissue formation over a 6-week follow-up in rabbits treated with two different grafting materials for maxillary sinus floor augmentation.This experimental animal study was conducted at the Experimental Medical Application and Research Center at Erzurum/ Turkey. Twelve New Zealand rabbits, each weighing between 2.7 and 3.3 kg, were used. Twenty-four maxillary sinus floor elevation operations were performed, two on each animal (n = 24). Each elevation was repaired with either deproteinized bovine bone (xenograft) or autogenous bone graft obtained from the iliac crest. Both groups were divided into 2 subgroups: saline-treated and alendronate-treated. All groups underwent the same surgical procedures and evaluation, and were sacrificed at the 6th postoperative week. Sinuses augmented with deproteinized bovine bone (xenograft) and autogenous bone graft were examined histopathologically and histomorphometrically.At 6 weeks, the bone area was significantly larger in the Xenograft-Alendronate group (33.0% ± 5.0%) than in the Xenograft-Saline group (20.8% ± 4.9%) and the bone area was significantly larger in the Autogenous-Alendronate group (43.3% ± 3.8%) than in the Autogenous-Saline group (37.5% ± 6.6%) (P = 0.001). The histomorphometric and histopathological results consistently showed that alendronate stimulated bone formation and reduced fibrous tissue formation in maxillary sinus augmentation grafts, especially in the deproteinized bovine bone group (xenograft).Alendronate may be considered a therapeutic option for improving the bone formation process and reducing resorption in different bone grafting procedures. Further detailed studies should focus on dosage and time-dependent effects of alendronate on bone remodeling." @default.
- W2201477891 created "2016-06-24" @default.
- W2201477891 creator A5030252781 @default.
- W2201477891 creator A5049013632 @default.
- W2201477891 creator A5061475092 @default.
- W2201477891 creator A5089215644 @default.
- W2201477891 date "2015-12-27" @default.
- W2201477891 modified "2023-10-16" @default.
- W2201477891 title "The Effect of Alendronate on Various Graft Materials Used in Maxillary Sinus Augmentation: A Rabbit Study" @default.
- W2201477891 cites W141011948 @default.
- W2201477891 cites W1531404162 @default.
- W2201477891 cites W1562545959 @default.
- W2201477891 cites W1578500257 @default.
- W2201477891 cites W1964803736 @default.
- W2201477891 cites W1970139228 @default.
- W2201477891 cites W1973253731 @default.
- W2201477891 cites W1975522166 @default.
- W2201477891 cites W1975572558 @default.
- W2201477891 cites W1976352034 @default.
- W2201477891 cites W1976620862 @default.
- W2201477891 cites W1979577268 @default.
- W2201477891 cites W1981521325 @default.
- W2201477891 cites W1986348761 @default.
- W2201477891 cites W1991359586 @default.
- W2201477891 cites W1994469664 @default.
- W2201477891 cites W2000823126 @default.
- W2201477891 cites W2010110993 @default.
- W2201477891 cites W2014262971 @default.
- W2201477891 cites W2023621890 @default.
- W2201477891 cites W2027335638 @default.
- W2201477891 cites W2038306792 @default.
- W2201477891 cites W2050210380 @default.
- W2201477891 cites W2066269571 @default.
- W2201477891 cites W2067228195 @default.
- W2201477891 cites W2068214967 @default.
- W2201477891 cites W2071868823 @default.
- W2201477891 cites W2084074207 @default.
- W2201477891 cites W2085739273 @default.
- W2201477891 cites W2094602038 @default.
- W2201477891 cites W2094920892 @default.
- W2201477891 cites W2099020399 @default.
- W2201477891 cites W2107782147 @default.
- W2201477891 cites W2116378947 @default.
- W2201477891 cites W2116790789 @default.
- W2201477891 cites W2130186495 @default.
- W2201477891 cites W2138237202 @default.
- W2201477891 cites W2142670098 @default.
- W2201477891 cites W2154980296 @default.
- W2201477891 cites W2157214708 @default.
- W2201477891 cites W2396653303 @default.
- W2201477891 cites W2399962674 @default.
- W2201477891 cites W2410657582 @default.
- W2201477891 cites W2793265345 @default.
- W2201477891 cites W30121871 @default.
- W2201477891 cites W36538704 @default.
- W2201477891 cites W97706636 @default.
- W2201477891 doi "https://doi.org/10.5812/ircmj.33569" @default.
- W2201477891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4706848" @default.
- W2201477891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26756022" @default.
- W2201477891 hasPublicationYear "2015" @default.
- W2201477891 type Work @default.
- W2201477891 sameAs 2201477891 @default.
- W2201477891 citedByCount "8" @default.
- W2201477891 countsByYear W22014778912016 @default.
- W2201477891 countsByYear W22014778912017 @default.
- W2201477891 countsByYear W22014778912018 @default.
- W2201477891 countsByYear W22014778912019 @default.
- W2201477891 countsByYear W22014778912020 @default.
- W2201477891 countsByYear W22014778912021 @default.
- W2201477891 countsByYear W22014778912022 @default.
- W2201477891 crossrefType "journal-article" @default.
- W2201477891 hasAuthorship W2201477891A5030252781 @default.
- W2201477891 hasAuthorship W2201477891A5049013632 @default.
- W2201477891 hasAuthorship W2201477891A5061475092 @default.
- W2201477891 hasAuthorship W2201477891A5089215644 @default.
- W2201477891 hasBestOaLocation W22014778911 @default.
- W2201477891 hasConcept C126322002 @default.
- W2201477891 hasConcept C141071460 @default.
- W2201477891 hasConcept C146562846 @default.
- W2201477891 hasConcept C151279780 @default.
- W2201477891 hasConcept C157369684 @default.
- W2201477891 hasConcept C199343813 @default.
- W2201477891 hasConcept C2776337968 @default.
- W2201477891 hasConcept C2776407911 @default.
- W2201477891 hasConcept C2776541429 @default.
- W2201477891 hasConcept C2777251235 @default.
- W2201477891 hasConcept C2777397205 @default.
- W2201477891 hasConcept C2778705571 @default.
- W2201477891 hasConcept C2779079599 @default.
- W2201477891 hasConcept C59822182 @default.
- W2201477891 hasConcept C673006 @default.
- W2201477891 hasConcept C71924100 @default.
- W2201477891 hasConcept C86803240 @default.
- W2201477891 hasConceptScore W2201477891C126322002 @default.
- W2201477891 hasConceptScore W2201477891C141071460 @default.
- W2201477891 hasConceptScore W2201477891C146562846 @default.
- W2201477891 hasConceptScore W2201477891C151279780 @default.
- W2201477891 hasConceptScore W2201477891C157369684 @default.
- W2201477891 hasConceptScore W2201477891C199343813 @default.
- W2201477891 hasConceptScore W2201477891C2776337968 @default.