FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201538072> ?p ?o ?g. }

• W2201538072 endingPage "144" @default.
• W2201538072 startingPage "139" @default.
• W2201538072 abstract "BACKGROUND: Liver disease is the third leading cause of mortality in patients with cystic fibrosis (CF). However, detection of CF-associated liver disease (CFLD) is challenging. OBJECTIVE: To evaluate the diagnostic performance of noninvasive methods for the detection of CFLD with a focus on transient elastography (TE). METHODS: Patients at the Adult CF Clinic of Calgary and Southern Alberta (n=127) underwent liver stiffness measurement (LSM) by TE using the FibroScan (FS, Ecosens, France) M probe; aspartate amino-transferase to platelet ratio index (APRI) and FibroTest (FT) scores were also calculated. The diagnostic performance of these tools for the detection of CFLD (defined as two or more the following criteria: abnormal liver biochemistry, hepatomegaly or sonographic abnormalities other than steatosis) were compared using the area under ROC curves. RESULTS: Forty-seven percent of the cohort was male. The median age was 27 years (interquartile range [IQR] 22 to 37 years) and body mass index 21 kg/m 2 (IQR 19 kg/m 2 to 23 kg/m 2 ); 25% of patients were on ursodeoxycholic acid and 12% had undergone lung transplantation. The prevalence of CFLD was 14% (n=18). FS was successful in all patients; one (0.8%) patient had poorly reliable results (IQR/M >30% and LSM ≥7.1kPa). Compared with patients without CFLD (n=109), individuals with CFLD had higher median LSM according to FS (3.9 kPa [IQR 3.4 to 4.9 kPa] versus 6.4 kPa [IQR 4.4 to 8.0 kPa]), APRI (0.24 [IQR 0.17 to 0.31] versus 0.50 [IQR 0.22 to 1.18]) and FT scores (0.08 [IQR 0.05 to 1.5] versus 0.18 [IQR 0.11 to 0.35]; all P<0.05). Area under ROC curve for FS, APRI and FT for the detection of CFLD were 0.78 (95% CI 0.65 to 0.92), 0.72 (95% CI 0.56 to 0.87) and 0.76 (95% CI 0.62 to 0.90) (P not significant). At a threshold of >5.2 kPa, the sensitivity, specificity, positive and negative predictive values of LSM according to FS for detecting CFLD were 67%, 83%, 40% and 94%, respectively. CONCLUSIONS: FS, APRI and FT were useful noninvasive methods for detecting CFLD in adults." @default.
• W2201538072 created "2016-06-24" @default.
• W2201538072 creator A5012451920 @default.
• W2201538072 creator A5013219986 @default.
• W2201538072 creator A5033823459 @default.
• W2201538072 creator A5038602145 @default.
• W2201538072 creator A5084223005 @default.
• W2201538072 creator A5088654582 @default.
• W2201538072 date "2015-01-01" @default.
• W2201538072 modified "2023-10-18" @default.
• W2201538072 title "Noninvasive Methods, including Transient Elastography, for the Detection of Liver Disease in Adults with Cystic Fibrosis" @default.
• W2201538072 cites W13771369 @default.
• W2201538072 cites W1858944688 @default.
• W2201538072 cites W1970900189 @default.
• W2201538072 cites W197291920 @default.
• W2201538072 cites W1978462916 @default.
• W2201538072 cites W1987425733 @default.
• W2201538072 cites W1987934823 @default.
• W2201538072 cites W1993309320 @default.
• W2201538072 cites W1995505992 @default.
• W2201538072 cites W1997865776 @default.
• W2201538072 cites W2000392384 @default.
• W2201538072 cites W2019951467 @default.
• W2201538072 cites W2020009872 @default.
• W2201538072 cites W2022241609 @default.
• W2201538072 cites W2024868833 @default.
• W2201538072 cites W2027496830 @default.
• W2201538072 cites W2042179107 @default.
• W2201538072 cites W2062566253 @default.
• W2201538072 cites W2065803484 @default.
• W2201538072 cites W2072861622 @default.
• W2201538072 cites W2079246556 @default.
• W2201538072 cites W2087928833 @default.
• W2201538072 cites W2092518819 @default.
• W2201538072 cites W2093904708 @default.
• W2201538072 cites W2096558363 @default.
• W2201538072 cites W2099997787 @default.
• W2201538072 cites W2109713965 @default.
• W2201538072 cites W2112748532 @default.
• W2201538072 cites W2120478186 @default.
• W2201538072 cites W2136336812 @default.
• W2201538072 cites W2141866917 @default.
• W2201538072 cites W2146286872 @default.
• W2201538072 cites W2149161940 @default.
• W2201538072 cites W2154739921 @default.
• W2201538072 cites W2156508801 @default.
• W2201538072 cites W2166947839 @default.
• W2201538072 cites W2328176404 @default.
• W2201538072 cites W317273140 @default.
• W2201538072 cites W4247258598 @default.
• W2201538072 doi "https://doi.org/10.1155/2015/138530" @default.
• W2201538072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4399373" @default.
• W2201538072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25855877" @default.
• W2201538072 hasPublicationYear "2015" @default.
• W2201538072 type Work @default.
• W2201538072 sameAs 2201538072 @default.
• W2201538072 citedByCount "31" @default.
• W2201538072 countsByYear W22015380722016 @default.
• W2201538072 countsByYear W22015380722017 @default.
• W2201538072 countsByYear W22015380722018 @default.
• W2201538072 countsByYear W22015380722019 @default.
• W2201538072 countsByYear W22015380722020 @default.
• W2201538072 countsByYear W22015380722021 @default.
• W2201538072 countsByYear W22015380722022 @default.
• W2201538072 countsByYear W22015380722023 @default.
• W2201538072 crossrefType "journal-article" @default.
• W2201538072 hasAuthorship W2201538072A5012451920 @default.
• W2201538072 hasAuthorship W2201538072A5013219986 @default.
• W2201538072 hasAuthorship W2201538072A5033823459 @default.
• W2201538072 hasAuthorship W2201538072A5038602145 @default.
• W2201538072 hasAuthorship W2201538072A5084223005 @default.
• W2201538072 hasAuthorship W2201538072A5088654582 @default.
• W2201538072 hasBestOaLocation W22015380721 @default.
• W2201538072 hasConcept C119060515 @default.
• W2201538072 hasConcept C126322002 @default.
• W2201538072 hasConcept C2776938444 @default.
• W2201538072 hasConcept C2777075537 @default.
• W2201538072 hasConcept C2777214474 @default.
• W2201538072 hasConcept C2779609443 @default.
• W2201538072 hasConcept C2780826214 @default.
• W2201538072 hasConcept C2911091166 @default.
• W2201538072 hasConcept C2994217296 @default.
• W2201538072 hasConcept C71924100 @default.
• W2201538072 hasConcept C72563966 @default.
• W2201538072 hasConcept C90924648 @default.
• W2201538072 hasConceptScore W2201538072C119060515 @default.
• W2201538072 hasConceptScore W2201538072C126322002 @default.
• W2201538072 hasConceptScore W2201538072C2776938444 @default.
• W2201538072 hasConceptScore W2201538072C2777075537 @default.
• W2201538072 hasConceptScore W2201538072C2777214474 @default.
• W2201538072 hasConceptScore W2201538072C2779609443 @default.
• W2201538072 hasConceptScore W2201538072C2780826214 @default.
• W2201538072 hasConceptScore W2201538072C2911091166 @default.
• W2201538072 hasConceptScore W2201538072C2994217296 @default.
• W2201538072 hasConceptScore W2201538072C71924100 @default.
• W2201538072 hasConceptScore W2201538072C72563966 @default.
• W2201538072 hasConceptScore W2201538072C90924648 @default.
• W2201538072 hasIssue "3" @default.

• next