FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201605744> ?p ?o ?g. }

• W2201605744 endingPage "9" @default.
• W2201605744 startingPage "1" @default.
• W2201605744 abstract "Background . Severe traumatization induces a complex pathophysiology, driven by the patient’s own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to evaluate the contribution of the RAGE axis to early and late immune responses. Methods . We enrolled 16 patients with severe trauma together with 10 patients after major abdominal surgery and 10 healthy volunteers. Blood samples were taken on admission and every 48 h for a total of 8 days. Plasma concentrations of various RAGE ligands as well as RAGE isoforms and IL-6 were measured by ELISA. Monocyte surface expression of RAGE and HLA-DR was assessed by flow cytometry. Results . High and transient levels of IL-6 and methylglyoxal characterize the early immune response after trauma, whereas samples from later time points provide evidence for a secondary release of RAGE ligands. Conclusion . Our results provide evidence for a persisting activation of the RAGE axis while classical mediators like IL-6 disappear early. Considering the immunocompromised phenotype of the monocytes, the RAGE ligands might be substantial contributors to the well-known secondary stage of impaired immune responsiveness in trauma patients." @default.
• W2201605744 created "2016-06-24" @default.
• W2201605744 creator A5009259632 @default.
• W2201605744 creator A5012512225 @default.
• W2201605744 creator A5012531468 @default.
• W2201605744 creator A5020824594 @default.
• W2201605744 creator A5029933928 @default.
• W2201605744 creator A5030354170 @default.
• W2201605744 creator A5033160716 @default.
• W2201605744 creator A5066377578 @default.
• W2201605744 creator A5067599146 @default.
• W2201605744 creator A5081699544 @default.
• W2201605744 creator A5086004448 @default.
• W2201605744 date "2015-01-01" @default.
• W2201605744 modified "2023-09-26" @default.
• W2201605744 title "Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study" @default.
• W2201605744 cites W1727418181 @default.
• W2201605744 cites W1989528047 @default.
• W2201605744 cites W1994190235 @default.
• W2201605744 cites W1999493479 @default.
• W2201605744 cites W2002459569 @default.
• W2201605744 cites W2006847300 @default.
• W2201605744 cites W2012522637 @default.
• W2201605744 cites W2015901595 @default.
• W2201605744 cites W2025680730 @default.
• W2201605744 cites W2033274423 @default.
• W2201605744 cites W2037516773 @default.
• W2201605744 cites W2043406394 @default.
• W2201605744 cites W2051083932 @default.
• W2201605744 cites W2057844010 @default.
• W2201605744 cites W2073446553 @default.
• W2201605744 cites W2078213156 @default.
• W2201605744 cites W2079815081 @default.
• W2201605744 cites W2081080245 @default.
• W2201605744 cites W2083559915 @default.
• W2201605744 cites W2088792593 @default.
• W2201605744 cites W2104317921 @default.
• W2201605744 cites W2106697731 @default.
• W2201605744 cites W2108762011 @default.
• W2201605744 cites W2112334970 @default.
• W2201605744 cites W2120293565 @default.
• W2201605744 cites W2127761382 @default.
• W2201605744 cites W2128591402 @default.
• W2201605744 cites W2133022777 @default.
• W2201605744 cites W2134219545 @default.
• W2201605744 cites W2141340790 @default.
• W2201605744 cites W2143394454 @default.
• W2201605744 cites W2144584318 @default.
• W2201605744 cites W2148570600 @default.
• W2201605744 cites W2150594596 @default.
• W2201605744 cites W2152377123 @default.
• W2201605744 cites W2168401684 @default.
• W2201605744 cites W2168710949 @default.
• W2201605744 cites W2170688086 @default.
• W2201605744 cites W2282244467 @default.
• W2201605744 cites W2314663946 @default.
• W2201605744 doi "https://doi.org/10.1155/2015/691491" @default.
• W2201605744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4736010" @default.
• W2201605744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26880860" @default.
• W2201605744 hasPublicationYear "2015" @default.
• W2201605744 type Work @default.
• W2201605744 sameAs 2201605744 @default.
• W2201605744 citedByCount "7" @default.
• W2201605744 countsByYear W22016057442017 @default.
• W2201605744 countsByYear W22016057442018 @default.
• W2201605744 countsByYear W22016057442020 @default.
• W2201605744 countsByYear W22016057442022 @default.
• W2201605744 crossrefType "journal-article" @default.
• W2201605744 hasAuthorship W2201605744A5009259632 @default.
• W2201605744 hasAuthorship W2201605744A5012512225 @default.
• W2201605744 hasAuthorship W2201605744A5012531468 @default.
• W2201605744 hasAuthorship W2201605744A5020824594 @default.
• W2201605744 hasAuthorship W2201605744A5029933928 @default.
• W2201605744 hasAuthorship W2201605744A5030354170 @default.
• W2201605744 hasAuthorship W2201605744A5033160716 @default.
• W2201605744 hasAuthorship W2201605744A5066377578 @default.
• W2201605744 hasAuthorship W2201605744A5067599146 @default.
• W2201605744 hasAuthorship W2201605744A5081699544 @default.
• W2201605744 hasAuthorship W2201605744A5086004448 @default.
• W2201605744 hasBestOaLocation W22016057441 @default.
• W2201605744 hasConcept C10162356 @default.
• W2201605744 hasConcept C126322002 @default.
• W2201605744 hasConcept C169760540 @default.
• W2201605744 hasConcept C170493617 @default.
• W2201605744 hasConcept C203014093 @default.
• W2201605744 hasConcept C2778857457 @default.
• W2201605744 hasConcept C2781184567 @default.
• W2201605744 hasConcept C553184892 @default.
• W2201605744 hasConcept C71924100 @default.
• W2201605744 hasConcept C86803240 @default.
• W2201605744 hasConcept C8891405 @default.
• W2201605744 hasConceptScore W2201605744C10162356 @default.
• W2201605744 hasConceptScore W2201605744C126322002 @default.
• W2201605744 hasConceptScore W2201605744C169760540 @default.
• W2201605744 hasConceptScore W2201605744C170493617 @default.
• W2201605744 hasConceptScore W2201605744C203014093 @default.
• W2201605744 hasConceptScore W2201605744C2778857457 @default.
• W2201605744 hasConceptScore W2201605744C2781184567 @default.

• next