Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201626758> ?p ?o ?g. }
- W2201626758 endingPage "48" @default.
- W2201626758 startingPage "3135" @default.
- W2201626758 abstract "Lung adenocarcinoma is characterized by complex biology involving alterations at the genomic and protein expression levels. FGFR2 mutation and/or amplification are key drivers of disease progression and drug resistance in lung adenocarcinoma patients. These genetic alterations drive oncogenic downstream signalling due to the deregulated activity of the receptor. We have previously reported that wild type FGFR2 provides a binding site for which two proteins, Grb2 and Plcγ1, compete in a concentration-dependent manner. Metastasis and invasion ensue when Plcγ1 prevails on the receptor giving rise to oncogenic outcome in the absence of gene mutation/deletion. The effect of this signalling mechanism on FGFR2-driven lung adenocarcinoma has not previously been considered. In this study we show that fluctuation in the combinatorial expression levels of FGFR2, Grb2 and Plcγ1 modulates cell invasive properties, tumor formation and is linked to recurrence-free survival in 150 lung adenocarcinoma patients. High levels of expression of FGFR2 and Plcγ1 in a low background of Grb2 significantly correlates with poor prognosis. On the other hand, low levels of expression of FGFR2 and Plcγ1 in a high background of Grb2 correlates with favourable prognosis. This study defines the expression pattern of FGFR2, Plcγ1 and Grb2 as a novel prognostic marker in human lung adenocarcinoma. Thus, consideration of the Grb2 and Plcγ1-mediated mechanism of FGFR2 regulation will enhance the therapeutic targeting of aberrant FGFR2 activity to provide the much-needed improvement to the treatment regimen of this high mortality disease." @default.
- W2201626758 created "2016-06-24" @default.
- W2201626758 creator A5009105122 @default.
- W2201626758 creator A5013738925 @default.
- W2201626758 creator A5017465418 @default.
- W2201626758 creator A5020514687 @default.
- W2201626758 creator A5028085268 @default.
- W2201626758 creator A5036444923 @default.
- W2201626758 creator A5043308930 @default.
- W2201626758 creator A5049475717 @default.
- W2201626758 creator A5053690456 @default.
- W2201626758 creator A5057051999 @default.
- W2201626758 creator A5060556083 @default.
- W2201626758 creator A5067562391 @default.
- W2201626758 creator A5082498438 @default.
- W2201626758 creator A5085468594 @default.
- W2201626758 date "2015-01-01" @default.
- W2201626758 modified "2023-09-23" @default.
- W2201626758 title "Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma." @default.
- W2201626758 cites W1808881593 @default.
- W2201626758 cites W1937853139 @default.
- W2201626758 cites W1979538859 @default.
- W2201626758 cites W1982158259 @default.
- W2201626758 cites W1982168338 @default.
- W2201626758 cites W1982740705 @default.
- W2201626758 cites W1988476050 @default.
- W2201626758 cites W1994075309 @default.
- W2201626758 cites W2004893350 @default.
- W2201626758 cites W2011993967 @default.
- W2201626758 cites W2013475220 @default.
- W2201626758 cites W2040935952 @default.
- W2201626758 cites W2042386784 @default.
- W2201626758 cites W2043696829 @default.
- W2201626758 cites W2053652371 @default.
- W2201626758 cites W2054841768 @default.
- W2201626758 cites W2055402151 @default.
- W2201626758 cites W2058310481 @default.
- W2201626758 cites W2062361320 @default.
- W2201626758 cites W2080783895 @default.
- W2201626758 cites W2091070104 @default.
- W2201626758 cites W2106787323 @default.
- W2201626758 cites W2113910336 @default.
- W2201626758 cites W2116338705 @default.
- W2201626758 cites W2131876608 @default.
- W2201626758 cites W2136549416 @default.
- W2201626758 cites W2139046059 @default.
- W2201626758 cites W2140965184 @default.
- W2201626758 cites W2143367532 @default.
- W2201626758 cites W2152358892 @default.
- W2201626758 cites W2158734599 @default.
- W2201626758 cites W2161608625 @default.
- W2201626758 cites W2161821474 @default.
- W2201626758 cites W2163798887 @default.
- W2201626758 cites W2168258970 @default.
- W2201626758 cites W2169154218 @default.
- W2201626758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4656736" @default.
- W2201626758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26693065" @default.
- W2201626758 hasPublicationYear "2015" @default.
- W2201626758 type Work @default.
- W2201626758 sameAs 2201626758 @default.
- W2201626758 citedByCount "7" @default.
- W2201626758 countsByYear W22016267582017 @default.
- W2201626758 countsByYear W22016267582018 @default.
- W2201626758 countsByYear W22016267582019 @default.
- W2201626758 countsByYear W22016267582020 @default.
- W2201626758 countsByYear W22016267582023 @default.
- W2201626758 crossrefType "journal-article" @default.
- W2201626758 hasAuthorship W2201626758A5009105122 @default.
- W2201626758 hasAuthorship W2201626758A5013738925 @default.
- W2201626758 hasAuthorship W2201626758A5017465418 @default.
- W2201626758 hasAuthorship W2201626758A5020514687 @default.
- W2201626758 hasAuthorship W2201626758A5028085268 @default.
- W2201626758 hasAuthorship W2201626758A5036444923 @default.
- W2201626758 hasAuthorship W2201626758A5043308930 @default.
- W2201626758 hasAuthorship W2201626758A5049475717 @default.
- W2201626758 hasAuthorship W2201626758A5053690456 @default.
- W2201626758 hasAuthorship W2201626758A5057051999 @default.
- W2201626758 hasAuthorship W2201626758A5060556083 @default.
- W2201626758 hasAuthorship W2201626758A5067562391 @default.
- W2201626758 hasAuthorship W2201626758A5082498438 @default.
- W2201626758 hasAuthorship W2201626758A5085468594 @default.
- W2201626758 hasConcept C101544691 @default.
- W2201626758 hasConcept C104317684 @default.
- W2201626758 hasConcept C121608353 @default.
- W2201626758 hasConcept C126322002 @default.
- W2201626758 hasConcept C143998085 @default.
- W2201626758 hasConcept C170493617 @default.
- W2201626758 hasConcept C177917778 @default.
- W2201626758 hasConcept C2776256026 @default.
- W2201626758 hasConcept C2777714996 @default.
- W2201626758 hasConcept C2779013556 @default.
- W2201626758 hasConcept C2779563347 @default.
- W2201626758 hasConcept C2781182431 @default.
- W2201626758 hasConcept C2781230642 @default.
- W2201626758 hasConcept C501734568 @default.
- W2201626758 hasConcept C502942594 @default.
- W2201626758 hasConcept C54355233 @default.
- W2201626758 hasConcept C71924100 @default.