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- W2201649470 abstract "Vitamin D is a unique nutrient and seco-steroid hormone, in that it can be given either as a daily, weekly, or monthly supplement to correct vitamin D status owing to the long circulating half-life (approximately 2 to 3 weeks) of its major metabolite, 25-hydroxyvitamin D (25[OH]D) ( 1. Ish-Shalom S. Segal E. Salganik T. Raz B. Bromberg IL. Vieth R. Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients. J Clin Endocrinol Metab. 2008; 93: 3430-3435 Crossref PubMed Scopus (178) Google Scholar , 2. Jones KS. Assar S. Harnpanich D. et al. 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. J Clin Endocrinol Metab. 2014; 99: 3373-3381 Crossref PubMed Scopus (155) Google Scholar ). There has been a great deal of interest in prescribing high-dose vitamin D for rapid correction of vitamin D status and/or as an adjunctive treatment for other diseases which may be modified by vitamin D therapy ( 3. Kearns MD. Alvarez JA. Tangpricha V. Large, single-dose, oral vitamin D supplementation in adult populations: a systematic review. Endocr Pract. 2014; 20: 341-351 Abstract Full Text Full Text PDF PubMed Scopus (78) Google Scholar ); however, there is no universally accepted regimen ( 4. Pepper KJ. Judd SE. Nanes MS. Tangpricha V. Evaluation of vitamin D repletion regimens to correct vitamin D status in adults. Endocr Pract. 2009; 15: 95-103 Abstract Full Text Full Text PDF PubMed Scopus (76) Google Scholar ). In the United States, high-dose bolus vitamin D is typically given as a capsule of 50,000 IU of vitamin D2 or vitamin D3. Both forms of vitamin D are available over the counter or by prescription, though only vitamin D2 is U.S. Food and Drug Administration (FDA) approved (despite evidence that high-dose vitamin D3 may be more effective in raising serum 25[OH]D concentrations) ( 5. Tripkovic L. Lambert H. Hart K. et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012; 95: 1357-1364 Crossref PubMed Scopus (458) Google Scholar ). However, intramuscular high-dose vitamin D has not been widely available due to variability in the potency of different vitamin D preparations and is not currently FDA approved ( 6. Whyte MP. Haddad Jr., JG. Variable potency of intramuscular vitamin D preparations. N Engl J Med. 1979; 300: 142 Crossref PubMed Scopus (5) Google Scholar )." @default.
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- W2201649470 date "2015-10-01" @default.
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- W2201649470 title "Driving Up the Dose: Implications for High-Dose Vitamin D Therapy" @default.
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