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- W2201658786 abstract "Over the past 30 years, as the expense and complications involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems (DDS). For many disease states, a substantial number of therapeutically effective compounds already exist. The effectiveness of these drugs is often limited by side effects or necessity to administer the compound in an ethical setting. The goal in designing sustained drug delivery is to reduce the frequency of dosing or to increase the effectiveness of the drug by localization at the site of action, reducing the dose required or providing uniform drug delivery. The design of oral sustained release DDS depends on various factors such as, physicochemical properties of drug, type of delivery system, disease being treated, and patient condition, and treatment duration, presence of food, gastrointestinal motility, and coadministration of other drugs. Keywords: Sustained release drug delivery system, Dose frequency, Biological half-life, Physicochemical properties of drugs." @default.
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- W2201658786 date "2015-09-01" @default.
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- W2201658786 title "FORMULATION APPROACHES FOR SUSTAINED RELEASE DOSAGE FORMS: A REVIEW" @default.
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