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- W2201713483 abstract "Object:To select an effective ingredient cochinchinenin A from EDB(Extract of Dragon's Blood) as pharmacokinetic study's object.Through the experiment,the pharmacokinetic law of Dragon's blood was initially understood.Method:The HPLC determination of Cochinchinenin A in mice blood plasma was first established.Then the concentration of Cochinchinenin A in plasma was determined at different time points after administration.Compartmental pharmacokinetic parameters were calculated using computer program 3P87.Results:Linear range of the method was in 50-500 ng/ml.The recovery rates of three kinds of concentrations were 114.80±2.86,103.60±4.38,101.80±2.12,respectively.The minimum detectable concentration was 10 ng/ml.The difference in the day was 1.28% and the difference out of the day was 2.26% and the precision was less than 3%;T(peak) was 77.73 min.C(max) was 224.99 ng/ml.T1/2Ke was 72.91 min.T1/2Kawas 40.94 min.V/F(C) was 1.019(mg/kg)/(ng/ml).AUC was 49553.47(ng/ml) min.Conclusions:The HPLC method had been established.The pharmacokinetic study of Cochinchinenin A was shown as one-compartment model.Cochinchinenin A's elimination half-life increased 178% compared with its absorption half-life.Cochinchinenin A could have great absorption and utilization after administration of EDB." @default.
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- W2201713483 date "2010-01-01" @default.
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- W2201713483 title "Pharmacokinetic study on effective ingredient Cochinchinenin A from Dragon's Blood extract in mice." @default.
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