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- W2201719384 abstract "To determine the optimum process conditions for dry granulating technique of Qibai Pingfei granule, granule excipient type, rolling wheel speed and pressure and feeding speed were studied. Taking shaping rate at a time, moisture absorption and dissolubility as index, the type and amount of granule excipient were determined. In addition, taking shaping rate at a time as index, parameters of rolling wheel speed and pressure and feeding speed were researched through single factor test and response surface methodology. The optimum parameters were as follows: lactose as excipient, dry extract powder to excipient at 1:2, rolling wheel speed and pressure at 10.9 Hz and 6.4 MPa and feeding speed at 7.2 Hz. After validation of three batches pilot-scale production, the optimum processing parameters for dry granulating technique of Qibai Pingfei granule is reasonable and feasible, which can provide reliable basis for production." @default.
- W2201719384 created "2016-06-24" @default.
- W2201719384 date "2015-08-01" @default.
- W2201719384 modified "2023-09-26" @default.
- W2201719384 title "Optimization of dry granulating technique of Qibai Pingfei granule through response surface methodology" @default.
- W2201719384 doi "https://doi.org/10.4268/cjcmm20151511" @default.
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- W2201719384 hasPublicationYear "2015" @default.
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