Matches in SemOpenAlex for { <https://semopenalex.org/work/W2201724206> ?p ?o ?g. }
- W2201724206 abstract "Genome duplication, thought to have happened twice early in vertebrate evolution and a third time in teleost fishes, gives rise to gene paralogs that can evolve subfunctions or neofunctions via sequence and regulatory changes. To explore the evolution and functions of corticotropin-releasing hormone (CRH), we searched sequenced teleost genomes for CRH paralogs. Our phylogenetic and synteny analyses indicate that two CRH genes, crha and crhb, evolved via duplication of crh1 early in the teleost lineage. We examined the expression of crha and crhb in two teleost species from different orders: an African cichlid, Burton's mouthbrooder, (Astatotilapia burtoni; Order Perciformes) and zebrafish (Danio rerio; Order Cypriniformes). Furthermore, we compared expression of the teleost crha and crhb genes with the crh1 gene of an outgroup to the teleost clade: the spotted gar (Lepisosteus oculatus). In situ hybridization for crha and crhb mRNA in brains and eyes revealed distinct expression patterns for crha in different teleost species. In the cichlid, crha mRNA was found in the retina but not in the brain. In zebrafish, however, crha mRNA was not found in the retina, but was detected in the brain, restricted to the ventral hypothalamus. Spotted gar crh1 was found in the retina as well as the brain, suggesting that the ancestor of teleost fishes likely had a crh1 gene expressed in both retina and brain. Thus, genome duplication may have freed crha from constraints, allowing it to evolve distinct sequences, expression patterns, and likely unique functions in different lineages." @default.
- W2201724206 created "2016-06-24" @default.
- W2201724206 creator A5039372193 @default.
- W2201724206 creator A5047089586 @default.
- W2201724206 date "2015-10-13" @default.
- W2201724206 modified "2023-10-17" @default.
- W2201724206 title "Divergent evolution of two corticotropin-releasing hormone (CRH) genes in teleost fishes" @default.
- W2201724206 cites W1545644237 @default.
- W2201724206 cites W1554773623 @default.
- W2201724206 cites W1578205033 @default.
- W2201724206 cites W1803885618 @default.
- W2201724206 cites W1913751214 @default.
- W2201724206 cites W1981067772 @default.
- W2201724206 cites W1981239255 @default.
- W2201724206 cites W1990304875 @default.
- W2201724206 cites W1991024712 @default.
- W2201724206 cites W1996250291 @default.
- W2201724206 cites W1998040022 @default.
- W2201724206 cites W2001564010 @default.
- W2201724206 cites W2005228725 @default.
- W2201724206 cites W2005774467 @default.
- W2201724206 cites W2010635754 @default.
- W2201724206 cites W2014943492 @default.
- W2201724206 cites W2016403923 @default.
- W2201724206 cites W2017519756 @default.
- W2201724206 cites W202431617 @default.
- W2201724206 cites W2025883006 @default.
- W2201724206 cites W2026561698 @default.
- W2201724206 cites W2027655271 @default.
- W2201724206 cites W2030794394 @default.
- W2201724206 cites W2031394080 @default.
- W2201724206 cites W2033166635 @default.
- W2201724206 cites W2034499270 @default.
- W2201724206 cites W2035733413 @default.
- W2201724206 cites W2035933769 @default.
- W2201724206 cites W2036507321 @default.
- W2201724206 cites W2037464735 @default.
- W2201724206 cites W2040415209 @default.
- W2201724206 cites W2040550641 @default.
- W2201724206 cites W2041736210 @default.
- W2201724206 cites W2044740581 @default.
- W2201724206 cites W2047405437 @default.
- W2201724206 cites W2049436456 @default.
- W2201724206 cites W2052647803 @default.
- W2201724206 cites W2055238787 @default.
- W2201724206 cites W2056564376 @default.
- W2201724206 cites W2063003229 @default.
- W2201724206 cites W2064912476 @default.
- W2201724206 cites W2065636600 @default.
- W2201724206 cites W2076597255 @default.
- W2201724206 cites W2077840052 @default.
- W2201724206 cites W2081778808 @default.
- W2201724206 cites W2086945639 @default.
- W2201724206 cites W2095036452 @default.
- W2201724206 cites W2097128462 @default.
- W2201724206 cites W2098739471 @default.
- W2201724206 cites W2102163928 @default.
- W2201724206 cites W2103087497 @default.
- W2201724206 cites W2103546861 @default.
- W2201724206 cites W2104116470 @default.
- W2201724206 cites W2104481260 @default.
- W2201724206 cites W2106641847 @default.
- W2201724206 cites W2110955276 @default.
- W2201724206 cites W2111335106 @default.
- W2201724206 cites W2113916199 @default.
- W2201724206 cites W2119990334 @default.
- W2201724206 cites W2128516932 @default.
- W2201724206 cites W2128880918 @default.
- W2201724206 cites W2132348979 @default.
- W2201724206 cites W2132432001 @default.
- W2201724206 cites W2132632499 @default.
- W2201724206 cites W2132808272 @default.
- W2201724206 cites W2144955265 @default.
- W2201724206 cites W2152075687 @default.
- W2201724206 cites W2156340505 @default.
- W2201724206 cites W2160378127 @default.
- W2201724206 cites W2164948861 @default.
- W2201724206 cites W2165933771 @default.
- W2201724206 cites W2166187656 @default.
- W2201724206 cites W2168107590 @default.
- W2201724206 cites W2168521535 @default.
- W2201724206 cites W2171008992 @default.
- W2201724206 cites W2180681519 @default.
- W2201724206 cites W2484659268 @default.
- W2201724206 cites W2581259096 @default.
- W2201724206 cites W4229487902 @default.
- W2201724206 cites W4376848280 @default.
- W2201724206 doi "https://doi.org/10.3389/fnins.2015.00365" @default.
- W2201724206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4602089" @default.
- W2201724206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26528116" @default.
- W2201724206 hasPublicationYear "2015" @default.
- W2201724206 type Work @default.
- W2201724206 sameAs 2201724206 @default.
- W2201724206 citedByCount "41" @default.
- W2201724206 countsByYear W22017242062016 @default.
- W2201724206 countsByYear W22017242062017 @default.
- W2201724206 countsByYear W22017242062018 @default.
- W2201724206 countsByYear W22017242062019 @default.
- W2201724206 countsByYear W22017242062020 @default.
- W2201724206 countsByYear W22017242062021 @default.