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- W2201738753 abstract "The actin cytoskeleton plays a crucial role in transmitting forces generated by molecular processes to cellular length scales to control the morphological and physical behaviors of cells. Force transmission from the molecular to cellular scale is well understood in the context of myosin II-mediated forces occurring in highly organized myofibrils found in striated muscle. However, diverse actomyosin organization found in non-muscle cells and utilized to effect shape change and force generation in cell adhesion, migration and division. The mechanical behaviors of such disordered actomyosin networks and bundles are not well understood. Our lab has developed approaches to study these questions by comparing quantitative biophysical measurements on live cells and in vitro reconstitutions with simulation and theory. I will discuss our recent data on force transmission in disordered actomyosin assemblies in the context of cell adhesion and migration." @default.
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- W2201738753 date "2012-03-02" @default.
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- W2201738753 title "Force Transmission in the Actin Cytoskeleton" @default.
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