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- W2201931036 abstract "White adipose tissue is composed of mature adipocytes, precursors (preadipocytes), endothelial cells, macrophages and other immune cells. The phenotype, amount and biology of each adipose tissue component are profoundly altered in human obesity. Low-grade inflammation both at the local and systemic levels characterizes obesity and appears to have a key role in mediating the consequence of increase adipose tissue mass on metabolic and vascular comorbidities. Moreover, a new concept of accumulation of extracellular matrix (ECM) components in adipose tissue has been recently proposed. Integrity of the ECM is essential for the proper development of adipose tissue in a physiological context. In pathologic conditions, more knowledge is nevertheless necessary to understand the contribution of ECM modifications and the consequence of fibrous depots. Observations in morbidly obese subjects suggest that the amount of fibrosis might hamper fat mass loss induced by surgery." @default.
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- W2201931036 date "2013-09-25" @default.
- W2201931036 modified "2023-09-26" @default.
- W2201931036 title "Histologie du tissu adipeux blanc normal et pathologique" @default.
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- W2201931036 doi "https://doi.org/10.1007/s11690-013-0404-7" @default.
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