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- W2201941804 abstract "In budding yeast, telomere homeostasis relies on a telomere-dedicated RPA-like (t-RPA) complex composed of the single-strand DNA binding protein Cdc13 in association with Stn1 and Ten1. While bound to telomeres, the t-RPA complex recruits telomerase to its site of action, and it performs an essential function which is widely assumed to be protection from unregulated resection. A current model assumes that these two events occur following completion of replication. We present here a substantially different model. Specifically, we propose that the t-RPA complex is a replication factor which associates with telomeres as the replisome proceeds into the G-rich telomeric duplex tract. Once associated with the replisome, the t-RPA complex facilitates replication of duplex telomeric DNA by (i) preventing replication fork collapse, which we propose is the essential role of the t-RPA complex and (ii) resolving collapsed forks by recruiting telomerase to the site of fork collapse. This model is supported by analysis of the sequence of duplex telomeric DNA in mutant strains, which reveals a role for both t-RPA and other telomere proteins in progression of the replisome through duplex telomeric DNA." @default.
- W2201941804 created "2016-06-24" @default.
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- W2201941804 creator A5051761061 @default.
- W2201941804 date "2012-04-01" @default.
- W2201941804 modified "2023-09-23" @default.
- W2201941804 title "Telomere Homeostasis in Budding Yeast is Regulated by a Single Mechanism Involving Replication Fork Collapse" @default.
- W2201941804 doi "https://doi.org/10.1096/fasebj.26.1_supplement.933.5" @default.
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