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- W2201941985 abstract "This chapter focuses on the process of reverse cholesterol transport. As peripheral cells do not degrade cholesterol, the only mechanism for removal is by efflux of intact free (unesterified) cholesterol molecules. Such molecules enter the “reverse cholesterol transport” pathway whereby they are delivered to the liver, converted to bile acids, and then excreted from the body. On the basis of an inverse correlation between serum high-density lipoprotein (HDL) levels and the incidence of atherosclerosis in the population, the purported lipoprotein vehicle for this transport is HDL. Cellular cholesterol pools can be labeled using exogenous cholesterol or by supplying labeled precursors. In either case, sufficient incubation times are needed to ensure the equilibration of the label among all subcellular pools. When using the exogenous labeling approach all radiolabeled cholesterol should be repurified prior to use. Repurification is necessary to remove oxidized compounds that, because of their increased polarity, exchange more rapidly than cholesterol." @default.
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- W2201941985 date "1986-01-01" @default.
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- W2201941985 title "Reverse cholesterol transport" @default.
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- W2201941985 doi "https://doi.org/10.1016/0076-6879(86)29095-3" @default.
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