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• W2202092674 startingPage "2546" @default.
• W2202092674 abstract "Microtubule dynamics in cells are regulated by associated proteins that can be either stabilizers or destabilizers. A class of destabilizers that is important in a large number of cellular activities is the microtubule-severing enzymes, yet little is known about how they function. Katanin p60 was the first ATPase associated with microtubule severing. Here, we investigate the activity of katanin severing using a GFP-labeled human version. We quantify the effect of katanin concentration on katanin binding and severing activity. We find that free tubulin can inhibit severing activity by interfering with katanin binding to microtubules. The inhibition is mediated by the sequence of the tubulin and specifically depends on the carboxy-terminal tails. We directly investigate the inhibition effect of tubulin carboxy-terminal tails using peptide sequences of α-, β-, or detyrosinated α-tubulin tails that have been covalently linked to bovine serum albumin. Our results show that β-tubulin tails are the most effective at inhibiting severing, and that detyrosinated α-tubulin tails are the least effective. These results are distinct from those for other severing enzymes and suggest a scheme for regulation of katanin activity in cells dependent on free tubulin concentration and the modification state of the tubulin." @default.
• W2202092674 created "2016-06-24" @default.
• W2202092674 creator A5025708608 @default.
• W2202092674 creator A5059015146 @default.
• W2202092674 creator A5062674863 @default.
• W2202092674 date "2015-12-01" @default.
• W2202092674 modified "2023-10-13" @default.
• W2202092674 title "Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails" @default.
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• W2202092674 doi "https://doi.org/10.1016/j.bpj.2015.11.011" @default.
• W2202092674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4699919" @default.
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• W2202092674 hasPublicationYear "2015" @default.
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