FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2202197310> ?p ?o ?g. }

• W2202197310 endingPage "4100" @default.
• W2202197310 startingPage "4100" @default.
• W2202197310 abstract "AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA4100 Recent advances in our understanding of tumor biology have led to a major shift in the treatment strategy of non-small cell lung cancer (NSCLC) towards targeting aberrant signaling pathways caused by genetic alterations. Epidermal growth factor receptor ( EGFR ) gene mutations are found in a certain subset of patients with NSCLC, and are known to confer the sensitivity to EGFR tyrosine kinase inhibitors (EGFR-TKI), including gefitinib. Preclinical studies have shown that activating EGFR mutations constitutively enhance the signaling of intracellular cascades such as PI3K/Akt and Ras/Raf/MAPK pathways. However, the correlation between EGFR mutations and phosphorylation of EGFR and the activation of its downstream molecules has not been fully evaluated in clinical setting. To better understand these relationship, we studied the EGFR mutation status by direct sequence method as well as by immunohistochemical staining to investigate the protein expression level of EGFR, phosphorylated EGFR (p-EGFR), phosphorylated Akt (p-Akt), and phosphorylated MAPK (p-MAPK) in 93 surgically resected NSCLC patients. Clinical information was also obtained from these individuals to determine the impact of molecular changes on clinical characteristics and survival in patients with NSCLC. The results revealed that there were 37 (40%) patients whose tumor harboring EGFR mutations (1 in exon 18, 22 in exon 19, 14 in exon 21). Protein expression of EGFR, p-EGFR, p-Akt, and p-MAPK was detected in 61 (66%), 27 (29%), 58 (62%), and 41 (44%) patients, respectively. As expected, EGFR mutations were significantly associated with female gender, never-smoking history, and adenocarcinoma histology (P<0.05, each). Of note, p-Akt expression was also associated with female gender and never-smoking history, and it was frequently upregulated in tumors harboring EGFR mutations (P<0.05, each). Phosphorylation of EGFR was closely correlated with the EGFR protein expression (P<0.05), but not with the EGFR mutations. In regard to patient survival, none of the molecular biomarkers was predictive for survival after surgical resection, but p-MAPK expression was predictive for poor prognosis after gefitinib treatment in patients with postoperative recurrence (P<0.05), suggesting the strong linkage between p-MAPK expression and survival benefit from gefitinib. These results could provide new insights into the rational application of inhibitors of Akt and MAPK as single agent or in combination with EGFR-TKI for the treatment of NSCLC." @default.
• W2202197310 created "2016-06-24" @default.
• W2202197310 creator A5001518992 @default.
• W2202197310 creator A5001897650 @default.
• W2202197310 creator A5007888883 @default.
• W2202197310 creator A5019215192 @default.
• W2202197310 creator A5032055370 @default.
• W2202197310 creator A5039723911 @default.
• W2202197310 creator A5056477482 @default.
• W2202197310 creator A5062920555 @default.
• W2202197310 creator A5066700160 @default.
• W2202197310 creator A5074447395 @default.
• W2202197310 date "2008-05-01" @default.
• W2202197310 modified "2023-09-23" @default.
• W2202197310 title "Comprehensive analysis of EGFR signaling pathways in non-small cell lung cancer." @default.
• W2202197310 hasPublicationYear "2008" @default.
• W2202197310 type Work @default.
• W2202197310 sameAs 2202197310 @default.
• W2202197310 citedByCount "0" @default.
• W2202197310 crossrefType "journal-article" @default.
• W2202197310 hasAuthorship W2202197310A5001518992 @default.
• W2202197310 hasAuthorship W2202197310A5001897650 @default.
• W2202197310 hasAuthorship W2202197310A5007888883 @default.
• W2202197310 hasAuthorship W2202197310A5019215192 @default.
• W2202197310 hasAuthorship W2202197310A5032055370 @default.
• W2202197310 hasAuthorship W2202197310A5039723911 @default.
• W2202197310 hasAuthorship W2202197310A5056477482 @default.
• W2202197310 hasAuthorship W2202197310A5062920555 @default.
• W2202197310 hasAuthorship W2202197310A5066700160 @default.
• W2202197310 hasAuthorship W2202197310A5074447395 @default.
• W2202197310 hasConcept C104317684 @default.
• W2202197310 hasConcept C11960822 @default.
• W2202197310 hasConcept C121608353 @default.
• W2202197310 hasConcept C126322002 @default.
• W2202197310 hasConcept C170493617 @default.
• W2202197310 hasConcept C2776256026 @default.
• W2202197310 hasConcept C2777506169 @default.
• W2202197310 hasConcept C2779438470 @default.
• W2202197310 hasConcept C2780580887 @default.
• W2202197310 hasConcept C36823959 @default.
• W2202197310 hasConcept C42362537 @default.
• W2202197310 hasConcept C501734568 @default.
• W2202197310 hasConcept C502942594 @default.
• W2202197310 hasConcept C54355233 @default.
• W2202197310 hasConcept C57074206 @default.
• W2202197310 hasConcept C62478195 @default.
• W2202197310 hasConcept C71924100 @default.
• W2202197310 hasConcept C75217442 @default.
• W2202197310 hasConcept C86554907 @default.
• W2202197310 hasConcept C86803240 @default.
• W2202197310 hasConcept C95444343 @default.
• W2202197310 hasConceptScore W2202197310C104317684 @default.
• W2202197310 hasConceptScore W2202197310C11960822 @default.
• W2202197310 hasConceptScore W2202197310C121608353 @default.
• W2202197310 hasConceptScore W2202197310C126322002 @default.
• W2202197310 hasConceptScore W2202197310C170493617 @default.
• W2202197310 hasConceptScore W2202197310C2776256026 @default.
• W2202197310 hasConceptScore W2202197310C2777506169 @default.
• W2202197310 hasConceptScore W2202197310C2779438470 @default.
• W2202197310 hasConceptScore W2202197310C2780580887 @default.
• W2202197310 hasConceptScore W2202197310C36823959 @default.
• W2202197310 hasConceptScore W2202197310C42362537 @default.
• W2202197310 hasConceptScore W2202197310C501734568 @default.
• W2202197310 hasConceptScore W2202197310C502942594 @default.
• W2202197310 hasConceptScore W2202197310C54355233 @default.
• W2202197310 hasConceptScore W2202197310C57074206 @default.
• W2202197310 hasConceptScore W2202197310C62478195 @default.
• W2202197310 hasConceptScore W2202197310C71924100 @default.
• W2202197310 hasConceptScore W2202197310C75217442 @default.
• W2202197310 hasConceptScore W2202197310C86554907 @default.
• W2202197310 hasConceptScore W2202197310C86803240 @default.
• W2202197310 hasConceptScore W2202197310C95444343 @default.
• W2202197310 hasLocation W22021973101 @default.
• W2202197310 hasOpenAccess W2202197310 @default.
• W2202197310 hasPrimaryLocation W22021973101 @default.
• W2202197310 hasRelatedWork W2074293797 @default.
• W2202197310 hasRelatedWork W2086156450 @default.
• W2202197310 hasRelatedWork W2101563790 @default.
• W2202197310 hasRelatedWork W2108614046 @default.
• W2202197310 hasRelatedWork W2138939757 @default.
• W2202197310 hasRelatedWork W2164753308 @default.
• W2202197310 hasRelatedWork W2243547424 @default.
• W2202197310 hasRelatedWork W2286164709 @default.
• W2202197310 hasRelatedWork W2317812241 @default.
• W2202197310 hasRelatedWork W2590242125 @default.
• W2202197310 hasRelatedWork W2600355778 @default.
• W2202197310 hasRelatedWork W2763165298 @default.
• W2202197310 hasRelatedWork W2927636949 @default.
• W2202197310 hasRelatedWork W2944986725 @default.
• W2202197310 hasRelatedWork W2987816109 @default.
• W2202197310 hasRelatedWork W3016026352 @default.
• W2202197310 hasRelatedWork W3016393959 @default.
• W2202197310 hasRelatedWork W3032261046 @default.
• W2202197310 hasRelatedWork W3134511527 @default.
• W2202197310 hasRelatedWork W3201206110 @default.
• W2202197310 hasVolume "68" @default.
• W2202197310 isParatext "false" @default.
• W2202197310 isRetracted "false" @default.

• next