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• W2202453669 abstract "The mechanism of action of the proapoptotic gene bak has so far proved to be elusive. Early molecular clues suggested that bak functioned as a competitive inhibitor of protective members of the bc1-2 family. Although this might still be an explanation for the apoptosis induced by overexpression of bak in cells, more recent data suggests that bak may have a role distinct from the other proapoptotic gene, bax. Important questions remain to be answered for bak. In particular, different subcellular compartments are occupied in different cells, suggesting that a general bak function might disrupt the integrity of a number of key organelles." @default.
• W2202453669 created "2016-06-24" @default.
• W2202453669 creator A5073354313 @default.
• W2202453669 date "1999-01-01" @default.
• W2202453669 modified "2023-09-27" @default.
• W2202453669 title "Mechanism of Action of the Proapoptotic Gene Bak" @default.
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• W2202453669 doi "https://doi.org/10.1007/978-1-59259-720-8_10" @default.
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