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- W2202888892 abstract "Extensive glycan microarray and structural analyses reveal that human intelectin-1 interacts selectively with microbial glycan epitopes through recognition of a terminal 1,2-diol group, an interaction that would be blocked in human glycans such as α-Neu5Ac. The glycans displayed on mammalian cells can differ markedly from those on microbes. Such differences could, in principle, be 'read' by carbohydrate-binding proteins, or lectins. We used glycan microarrays to show that human intelectin-1 (hIntL-1) does not bind known human glycan epitopes but does interact with multiple glycan epitopes found exclusively on microbes: β-linked D-galactofuranose (β-Galf), D-phosphoglycerol–modified glycans, heptoses, D-glycero- D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D- manno-oct-2-ulosonic acid (KDO). The 1.6-Å-resolution crystal structure of hIntL-1 complexed with β-Galf revealed that hIntL-1 uses a bound calcium ion to coordinate terminal exocyclic 1,2-diols. N-acetylneuraminic acid (Neu5Ac), a sialic acid widespread in human glycans, has an exocyclic 1,2-diol but does not bind hIntL-1, probably owing to unfavorable steric and electronic effects. hIntL-1 marks only Streptococcus pneumoniae serotypes that display surface glycans with terminal 1,2-diol groups. This ligand selectivity suggests that hIntL-1 functions in microbial surveillance." @default.
- W2202888892 created "2016-06-24" @default.
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- W2202888892 date "2015-07-06" @default.
- W2202888892 modified "2023-10-10" @default.
- W2202888892 title "Recognition of microbial glycans by human intelectin-1" @default.
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- W2202888892 cites W1962430506 @default.
- W2202888892 cites W1972024114 @default.
- W2202888892 cites W1976974972 @default.
- W2202888892 cites W1979971768 @default.
- W2202888892 cites W1980914602 @default.
- W2202888892 cites W1988661614 @default.
- W2202888892 cites W2009727907 @default.
- W2202888892 cites W2015365611 @default.
- W2202888892 cites W2017446752 @default.
- W2202888892 cites W2022138753 @default.
- W2202888892 cites W2023690749 @default.
- W2202888892 cites W2023964275 @default.
- W2202888892 cites W2026858016 @default.
- W2202888892 cites W2027951805 @default.
- W2202888892 cites W2030517878 @default.
- W2202888892 cites W2038996493 @default.
- W2202888892 cites W2039737871 @default.
- W2202888892 cites W2044616525 @default.
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- W2202888892 cites W2055800251 @default.
- W2202888892 cites W2061321571 @default.
- W2202888892 cites W2061822610 @default.
- W2202888892 cites W2066863938 @default.
- W2202888892 cites W2068734008 @default.
- W2202888892 cites W2071466250 @default.
- W2202888892 cites W2072231121 @default.
- W2202888892 cites W2072572334 @default.
- W2202888892 cites W2077058827 @default.
- W2202888892 cites W2077590888 @default.
- W2202888892 cites W2078235464 @default.
- W2202888892 cites W2078479161 @default.
- W2202888892 cites W2092744829 @default.
- W2202888892 cites W2101994976 @default.
- W2202888892 cites W2104063702 @default.
- W2202888892 cites W2108563067 @default.
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- W2202888892 cites W2125782486 @default.
- W2202888892 cites W2128063537 @default.
- W2202888892 cites W2130622312 @default.
- W2202888892 cites W2130865959 @default.
- W2202888892 cites W2131085727 @default.
- W2202888892 cites W2131492616 @default.
- W2202888892 cites W2131799198 @default.
- W2202888892 cites W2136703107 @default.
- W2202888892 cites W2137597277 @default.
- W2202888892 cites W2142012795 @default.
- W2202888892 cites W2151763773 @default.
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- W2202888892 cites W2154714625 @default.
- W2202888892 cites W2163341755 @default.
- W2202888892 cites W2163644361 @default.
- W2202888892 cites W2165872127 @default.
- W2202888892 cites W2167985855 @default.
- W2202888892 cites W2168470451 @default.
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- W2202888892 doi "https://doi.org/10.1038/nsmb.3053" @default.
- W2202888892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4526365" @default.
- W2202888892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26148048" @default.
- W2202888892 hasPublicationYear "2015" @default.
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