Matches in SemOpenAlex for { <https://semopenalex.org/work/W2202942826> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2202942826 endingPage "7" @default.
- W2202942826 startingPage "60" @default.
- W2202942826 abstract "To determine whether monoalyers of cultured chick embryo ventricular cells would show tachyphylaxis to chronotropic and inotropic effects of a beta adrenergic agonist, spontaneously contracting monolayers of primary cell cultures were studied using a phase-contrast microscope-video motion detector system that permitted quantitation of the chronotropic and inotropic state. The monoalyers were chronotropically unresponsive to isoproterenol between 10(-9) to 10(-6) M and chronotropically unresponsive to a 6-fold increase in perfusate calcium concentration. However, the cells were very inotropically responsive to calcium and to isoproterenol. Expressing the isoproterenol inotropic response as a percentage of response to 3.6 mM Ca, the response to 10(-6) M isoproterenol was 79 +/- 4% of the Ca response and the EC50 for isoproterenol was 3 x 10(-9) M. The monolayers rapidly developed dose-dependent desensitization to the inotropic effect of isoproterenol; after a 30-min exposure to 1 x 10(-6) M isoproterenol, the inotropic response was 40 +/- 5% of the initial response; desensitization was long-lasting and could be prevented by propranolol. Response to calcium remained unchanged after exposure to 10(-6) M isoproterenol. Thus, the cultured cell preparation shows rapid, sustained, beta receptor specific desensitization to the inotropic effects of a catecholamine." @default.
- W2202942826 created "2016-06-24" @default.
- W2202942826 creator A5006718419 @default.
- W2202942826 creator A5064305448 @default.
- W2202942826 creator A5082857119 @default.
- W2202942826 date "1982-10-01" @default.
- W2202942826 modified "2023-09-23" @default.
- W2202942826 title "Desensitization to the inotropic effect of isoproterenol in cultured ventricular cells." @default.
- W2202942826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6288921" @default.
- W2202942826 hasPublicationYear "1982" @default.
- W2202942826 type Work @default.
- W2202942826 sameAs 2202942826 @default.
- W2202942826 citedByCount "15" @default.
- W2202942826 crossrefType "journal-article" @default.
- W2202942826 hasAuthorship W2202942826A5006718419 @default.
- W2202942826 hasAuthorship W2202942826A5064305448 @default.
- W2202942826 hasAuthorship W2202942826A5082857119 @default.
- W2202942826 hasConcept C126322002 @default.
- W2202942826 hasConcept C134018914 @default.
- W2202942826 hasConcept C155710745 @default.
- W2202942826 hasConcept C158328960 @default.
- W2202942826 hasConcept C168481208 @default.
- W2202942826 hasConcept C170493617 @default.
- W2202942826 hasConcept C185592680 @default.
- W2202942826 hasConcept C24998067 @default.
- W2202942826 hasConcept C2776090920 @default.
- W2202942826 hasConcept C2777953023 @default.
- W2202942826 hasConcept C2778151854 @default.
- W2202942826 hasConcept C2778938600 @default.
- W2202942826 hasConcept C2779779143 @default.
- W2202942826 hasConcept C519063684 @default.
- W2202942826 hasConcept C71924100 @default.
- W2202942826 hasConcept C84393581 @default.
- W2202942826 hasConceptScore W2202942826C126322002 @default.
- W2202942826 hasConceptScore W2202942826C134018914 @default.
- W2202942826 hasConceptScore W2202942826C155710745 @default.
- W2202942826 hasConceptScore W2202942826C158328960 @default.
- W2202942826 hasConceptScore W2202942826C168481208 @default.
- W2202942826 hasConceptScore W2202942826C170493617 @default.
- W2202942826 hasConceptScore W2202942826C185592680 @default.
- W2202942826 hasConceptScore W2202942826C24998067 @default.
- W2202942826 hasConceptScore W2202942826C2776090920 @default.
- W2202942826 hasConceptScore W2202942826C2777953023 @default.
- W2202942826 hasConceptScore W2202942826C2778151854 @default.
- W2202942826 hasConceptScore W2202942826C2778938600 @default.
- W2202942826 hasConceptScore W2202942826C2779779143 @default.
- W2202942826 hasConceptScore W2202942826C519063684 @default.
- W2202942826 hasConceptScore W2202942826C71924100 @default.
- W2202942826 hasConceptScore W2202942826C84393581 @default.
- W2202942826 hasIssue "1" @default.
- W2202942826 hasLocation W22029428261 @default.
- W2202942826 hasOpenAccess W2202942826 @default.
- W2202942826 hasPrimaryLocation W22029428261 @default.
- W2202942826 hasRelatedWork W1964190454 @default.
- W2202942826 hasRelatedWork W1981015702 @default.
- W2202942826 hasRelatedWork W1984748936 @default.
- W2202942826 hasRelatedWork W2005881152 @default.
- W2202942826 hasRelatedWork W2014480479 @default.
- W2202942826 hasRelatedWork W2045341648 @default.
- W2202942826 hasRelatedWork W2202942826 @default.
- W2202942826 hasRelatedWork W2411297412 @default.
- W2202942826 hasRelatedWork W2413535717 @default.
- W2202942826 hasRelatedWork W2415513637 @default.
- W2202942826 hasVolume "223" @default.
- W2202942826 isParatext "false" @default.
- W2202942826 isRetracted "false" @default.
- W2202942826 magId "2202942826" @default.
- W2202942826 workType "article" @default.