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• W2203046332 abstract "In the last 10 years, the role of mesenchymal stromal cells (MSCs) in modulating inflammatory and immune responses has been characterized using both in vitro studies and in vivo models of immune disorders. Mesenchymal stromal cell immunomodulatory properties have been linked to various paracrine factors which expression varies depending on the pathologic condition to which the MSCs are exposed. These factors may directly impact key cells of the adaptive immune system, such as T cells. Indeed, coculturing MSCs with T cells in a mixed lymphocyte reaction assay inhibits T-cell proliferation through the secretion of immunomodulatory cytokines. However, in a context of inflammation, MSCs may secrete paracrine factors that influence other immune cell subpopulations such as dendritic cells and macrophages and polarize them toward a tolerogenic phenotype. In vivo, these same immunomodulatory factors are shown to be increased in the serum of animal models presenting with inflammatory diseases treated with MSC administration. In light of the results from these landmark studies, we review the main MSC secreted factors identified to play a role in modulating inflammatory immune responses either in vitro or in vivo, and we assess the impact of these factors on the therapeutic applications of MSC-based cell therapies in immune diseases." @default.
• W2203046332 created "2016-06-24" @default.
• W2203046332 creator A5025943973 @default.
• W2203046332 creator A5028050718 @default.
• W2203046332 creator A5055458842 @default.
• W2203046332 creator A5071229466 @default.
• W2203046332 date "2016-01-01" @default.
• W2203046332 modified "2023-10-01" @default.
• W2203046332 title "Unraveling the Mesenchymal Stromal Cells' Paracrine Immunomodulatory Effects" @default.
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• W2203046332 doi "https://doi.org/10.1016/j.tmrv.2015.11.004" @default.
• W2203046332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26689863" @default.
• W2203046332 hasPublicationYear "2016" @default.
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