Matches in SemOpenAlex for { <https://semopenalex.org/work/W2203487265> ?p ?o ?g. }
- W2203487265 endingPage "C1439" @default.
- W2203487265 startingPage "C1431" @default.
- W2203487265 abstract "Our goal was to examine the sidedness of effects of the purinergic agonist, uridine 5′-triphosphate (UTP), on Cl − secretion in intestinal epithelial cells. We hypothesized that UTP might exert both stimulatory and inhibitory effects. All studies were conducted with T84 intestinal epithelial cells. UTP induced Cl − secretion in a concentration-dependent fashion. Responses to serosally added UTP were smaller and more transient than those evoked by mucosal addition, but there was no evidence that mucosal responses involved cAMP-dependent mechanisms. Pretreatment with serosal UTP inhibited subsequent Ca 2+ -dependent Cl − secretion induced by carbachol or thapsigargin, or secretion induced by mucosal UTP, in a manner that was reversed by a tyrosine kinase inhibitor. The inhibitory effect of serosal UTP on Cl − secretion was not additive with that of carbachol, known to exert its inhibitory effects through the tyrosine kinase-dependent generation of inositol 3,4,5,6-tetrakisphosphate [Ins(3,4,5,6) P 4 ]. Moreover, responses to both serosal and mucosal UTP were reduced by prior treatment of T84 cells with carbachol. Finally, serosal, but not mucosal, UTP evoked an increase in Ins(3,4,5,6) P 4 . We conclude that different signaling mechanisms lie downstream of apical and basolateral UTP receptors in epithelial cells, at least in the intestine. These differences may be relevant to the use of UTP as a therapy in cystic fibrosis." @default.
- W2203487265 created "2016-06-24" @default.
- W2203487265 creator A5001059601 @default.
- W2203487265 creator A5062223587 @default.
- W2203487265 date "2001-06-01" @default.
- W2203487265 modified "2023-10-16" @default.
- W2203487265 title "Differential effects of apical and basolateral uridine triphosphate on intestinal epithelial chloride secretion" @default.
- W2203487265 cites W132866068 @default.
- W2203487265 cites W1484192189 @default.
- W2203487265 cites W1522298610 @default.
- W2203487265 cites W1553673732 @default.
- W2203487265 cites W1573745866 @default.
- W2203487265 cites W1573846225 @default.
- W2203487265 cites W1786021994 @default.
- W2203487265 cites W1802980406 @default.
- W2203487265 cites W1821976079 @default.
- W2203487265 cites W1837800817 @default.
- W2203487265 cites W1841845280 @default.
- W2203487265 cites W1940339796 @default.
- W2203487265 cites W1983297072 @default.
- W2203487265 cites W1989678156 @default.
- W2203487265 cites W1989684860 @default.
- W2203487265 cites W1995068063 @default.
- W2203487265 cites W1997908015 @default.
- W2203487265 cites W1999495254 @default.
- W2203487265 cites W2022322532 @default.
- W2203487265 cites W2024337798 @default.
- W2203487265 cites W2032072813 @default.
- W2203487265 cites W2033490823 @default.
- W2203487265 cites W2034721124 @default.
- W2203487265 cites W2044232232 @default.
- W2203487265 cites W2045547109 @default.
- W2203487265 cites W2048680763 @default.
- W2203487265 cites W2049549444 @default.
- W2203487265 cites W2052062627 @default.
- W2203487265 cites W2055497515 @default.
- W2203487265 cites W2059232582 @default.
- W2203487265 cites W2060852213 @default.
- W2203487265 cites W2062914790 @default.
- W2203487265 cites W2090429326 @default.
- W2203487265 cites W2095736329 @default.
- W2203487265 cites W2114465292 @default.
- W2203487265 cites W2116365881 @default.
- W2203487265 cites W2123382745 @default.
- W2203487265 cites W2136025669 @default.
- W2203487265 cites W2141626158 @default.
- W2203487265 cites W2144408702 @default.
- W2203487265 cites W2152728266 @default.
- W2203487265 cites W2177771047 @default.
- W2203487265 cites W2181923630 @default.
- W2203487265 cites W2186898166 @default.
- W2203487265 cites W2187516635 @default.
- W2203487265 cites W2249098407 @default.
- W2203487265 cites W2263212714 @default.
- W2203487265 cites W2269095518 @default.
- W2203487265 cites W2273127291 @default.
- W2203487265 cites W2305508472 @default.
- W2203487265 cites W2338243080 @default.
- W2203487265 cites W2398692990 @default.
- W2203487265 cites W2399665621 @default.
- W2203487265 cites W2404185951 @default.
- W2203487265 cites W2406208122 @default.
- W2203487265 cites W2407398125 @default.
- W2203487265 cites W2409622650 @default.
- W2203487265 cites W2412076480 @default.
- W2203487265 cites W2418970941 @default.
- W2203487265 cites W2441878559 @default.
- W2203487265 cites W2472027441 @default.
- W2203487265 cites W4247861136 @default.
- W2203487265 cites W63235074 @default.
- W2203487265 doi "https://doi.org/10.1152/ajpcell.2001.280.6.c1431" @default.
- W2203487265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11350738" @default.
- W2203487265 hasPublicationYear "2001" @default.
- W2203487265 type Work @default.
- W2203487265 sameAs 2203487265 @default.
- W2203487265 citedByCount "21" @default.
- W2203487265 countsByYear W22034872652012 @default.
- W2203487265 countsByYear W22034872652013 @default.
- W2203487265 countsByYear W22034872652016 @default.
- W2203487265 countsByYear W22034872652019 @default.
- W2203487265 countsByYear W22034872652022 @default.
- W2203487265 crossrefType "journal-article" @default.
- W2203487265 hasAuthorship W2203487265A5001059601 @default.
- W2203487265 hasAuthorship W2203487265A5062223587 @default.
- W2203487265 hasBestOaLocation W22034872652 @default.
- W2203487265 hasConcept C104317684 @default.
- W2203487265 hasConcept C126322002 @default.
- W2203487265 hasConcept C134018914 @default.
- W2203487265 hasConcept C160225129 @default.
- W2203487265 hasConcept C170493617 @default.
- W2203487265 hasConcept C185592680 @default.
- W2203487265 hasConcept C2776938444 @default.
- W2203487265 hasConcept C2776991684 @default.
- W2203487265 hasConcept C2777226302 @default.
- W2203487265 hasConcept C2777427919 @default.
- W2203487265 hasConcept C2778428886 @default.
- W2203487265 hasConcept C2778564976 @default.
- W2203487265 hasConcept C2778618036 @default.