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- W2203516733 abstract "Egg activation is a crucial step that initiates embryo development upon breaking the meiotic arrest. In mammalian, egg activation is accomplished by fusion with sperm, which induces the repeated intracellular Ca 2+ - increases ([Ca 2+ ] i oscillation). Researches in mammals support the view of the [Ca 2+ ] i oscillation and egg activation is triggered by a protein factor from sperm that causes [Ca 2+ ] i release from endoplasmic reticulum, intracellular [Ca 2+ ] i store, by persistently activation of phosphoinositide pathway. It represents that the sperm factor generates production of inositol trisphosphate (IP 3 ). Recently a sperm specific form of phospholipase C zeta, referred to as PLCZ was identified. 1n this paper, we confer the evidence that PLCZ represent the sperm factor that induces [Ca 2+ ] i oscillation and egg activation and discuss the correlation of PLCZ and infertility." @default.
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- W2203516733 date "2011-09-01" @default.
- W2203516733 modified "2023-09-27" @default.
- W2203516733 title "Production of Intracellular Calcium Oscillation by Phospholipase C Zeta Activation in Mammalian Eggs" @default.
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