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- W22036205 abstract "AIM: To explore the role of microenvironment of peritoneal fluid in pathogenesis of endometriosis, the source and its regulation in peritoneal fluid. METHODS: Peritoneal MΦs from 14 patients with endometriosis (endometriosis group) and 10 normal women (control group) were cultured in vitro . Either 17 β estradiol, prosgesterone and LPS or their combinant were added to cultured peritoneal MΦs from control group. VEGF levels in culture supernatant of MΦs from two groups were detected by ELISA. Culture supernatant of serum free media in two groups were added to the cultured endothelial cells. Effect of the supernatant on endothelial cell proliferation activity was examined by MTT colorimetry at wavelength of 450 nm. The expressions of Flt 1 and Flt 4 on the MΦs from two groups were determined by immunohistochemical staining. RESULTS: The VEGF level in culture supernatant of MΦs from endometriosis group was significantly higher than that from control group( P 0.05), and had no cyclic variation( P 0.05). As compared with LPS, estrogen and progentrogen could elevate notably the level of VEGF secreted by MΦs( P 0.05). However, the regulation of MΦs secreted VEGF level by estrogen and progestoron had no marked difference. The MΦs activated by LPS could strengthen the regulation of VEGF secreted by MΦs under estrogen and progestron stimulation. Culture supernatant of serum free media for MΦs could promote significantly the proliferation of endothelial cells( P 0.05). Flt 1 and Flt 4 on MΦs was expressed without cyclic variation ( P 0.05) . CONCLUSION: The VEGF may be secreted by MΦs in peritoneal fluid of endometriosis group. The endothelial cell proliferation and angiogenesis are enhanced by change of microenvironment of peritoneal fluid." @default.
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- W22036205 date "2003-09-01" @default.
- W22036205 modified "2023-09-23" @default.
- W22036205 title "VEGF production and its receptor expression of MPhis in peritoneal fluid" @default.
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