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• W2203622105 abstract "The sequence-specific transcription factor p53 has been intensively studied over the past 35 years due to its critical tumor-suppressive functions in cells. Its importance is underscored by the finding that the gene is mutated in over 50% of all human tumor types, and loss of function removes a critical control mechanism for halting cellular growth. p53 is tightly regulated through a wide range of posttranslational modifications that control both protein levels and transcriptional activity. In addition to regulating cell growth in response to DNA damage and other cellular stress events, p53 also appears to play a substantial role in controlling cellular metabolism, which has implications on our understanding of how p53 acts in response to varying intensities of the stress event. This article will highlight the current understanding of how p53 is regulated and the pathways in which it is involved." @default.
• W2203622105 created "2016-06-24" @default.
• W2203622105 creator A5001967177 @default.
• W2203622105 date "2016-01-01" @default.
• W2203622105 modified "2023-10-16" @default.
• W2203622105 title "Regulation of the p53 Pathway" @default.
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• W2203622105 doi "https://doi.org/10.1016/b978-0-12-394447-4.30061-x" @default.
• W2203622105 hasPublicationYear "2016" @default.
• W2203622105 type Work @default.
• W2203622105 sameAs 2203622105 @default.

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