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- W2203674729 abstract "Nanosecond pulsed electric fields (nsPEFs) have received considerable attention because of their unique effects on living cells. Exposure of cultured cells to nsPEFs is known to induce Ca influx by forming small pores in the plasma membrane. Furthermore, nsPEFs have been reported to induce activation of multiple cellular signaling pathways. To examine the relationship between Ca influx and intracellular signaling events after nsPEF exposure, we applied nsPEFs to HeLa S3 cells suspended in either Ca-free or Ca-containing medium and analyzed the activation of signaling pathways. We observed that the presence of extracellular Ca was required for AMPK activation but dispensable for the initiation of stress responses in nsPEF-exposed HeLa S3 cells. JNK and p38, which are major regulatory factors in MAPK pathways, were activated by nsPEFs irrespective of the presence or absence of extracellular Ca. The absence of extracellular Ca, however, led to augmented phosphorylation of JNK and p38, suggesting positive effects of Ca influx on negative feedback controls in MAPK pathways. Taken together, these observations demonstrate that Ca influx induced by nsPEFs differentially participates in intracellular signaling events." @default.
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- W2203674729 date "2015-10-29" @default.
- W2203674729 modified "2023-09-27" @default.
- W2203674729 title "Extracellular calcium differentially affects intracellular responses to nanosecond pulsed electric fields" @default.
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