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- W2203767863 abstract "The antibacterial and cytotoxic effects of metabolites isolated from an antibacterial extract of Flourensia oolepis were evaluated. Bioguided fractionation led to five flavonoids, identified as 2′,4′-dihydroxychalcone ( 1 ), isoliquiritigenin ( 2 ), pinocembrin ( 3 ), 7-hydroxyflavanone ( 4 ), and 7,4′-dihydroxy-3′-methoxyflavanone ( 5 ). Compound 1 showed the highest antibacterial effect, with minimum inhibitory concentration (MIC) values ranging from 31 to 62 and 62 to 250 μ g/mL, against Gram-positive and Gram-negative bacteria, respectively. On further assays, the cytotoxic effect of compounds 1 – 5 was determined by MTT assay on acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML) cell lines including their multidrug resistant (MDR) phenotypes. Compound 1 induced a remarkable cytotoxic activity toward ALL cells (IC 50 = 6.6–9.9 μ M) and a lower effect against CML cells (IC 50 = 27.5–30.0 μ M). Flow cytometry was used to analyze cell cycle distribution and cell death by PI-labeled cells and by Annexin V/PI staining, respectively. Upon treatment, 1 induced cell cycle arrest in the G 2 /M phase accompanied by a strong induction of apoptosis. These results describe for the first time the antibacterial metabolites of F. oolepis extract, with 1 being the most effective. This chalcone also emerges as a selective cytotoxic agent against sensitive and resistant leukemic cells, highlighting its potential as a lead compound." @default.
- W2203767863 created "2016-06-24" @default.
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- W2203767863 date "2015-01-01" @default.
- W2203767863 modified "2023-10-07" @default.
- W2203767863 title "Antibacterial and Cytotoxic Activity of Compounds Isolated from<i>Flourensia oolepis</i>" @default.
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- W2203767863 doi "https://doi.org/10.1155/2015/912484" @default.
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