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- W2203846916 abstract "THE VALUE of the vaginal smear method for the study of ovarian functions is based upon the response of the vaginal epithelium to the hormones of the ovary. This relationship has been long evident from comparison of the structure of the undeveloped vagina in childhood and the atrophic mucosa of senility with the histologically normal, fully developed epithelial structure characteristic in sexual maturity; it has more recently also been indicated by the apparent occurrence of rhythmic alterations of the vaginal epithelium during the menstrual cycle. These changes have been accepted by many as proof of a human vaginal cycle. Papanicolaou's publication in 1933, supporting this belief, indicated that such cyclic variations could readily be demonstrated in stained smears of human vaginal fluid (1). A later publication, with Shorr in 1936, described the vaginal cytology of the menopause and advocated the vaginal smear method for the diagnosis of ovarian failure, at the same time demonstrating clearly the morphol..." @default.
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- W2203846916 date "1943-03-01" @default.
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- W2203846916 title "Vaginal Smear Technic" @default.
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- W2203846916 doi "https://doi.org/10.1210/jcem-3-3-169" @default.
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