FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2203898014> ?p ?o ?g. }

• W2203898014 endingPage "212" @default.
• W2203898014 startingPage "171" @default.
• W2203898014 abstract "This literature review presents available data on the metabolism of diethylstilbestrol (DES) to shed light on the fate and the mechanism of toxicity of this compound. Biotransformation effects reviewed include conjugation reactions of DES such as glucuronide formation in vivo and in vitro, enterohepatic circulation of DES and its glucuronide, and formation of steroid sulfatases and sulfates; oxidative metabolism of DES (aromatic hydroxylation followed by methylation); and species differences in DES metabolism. Excretion curves for 12 animal species show vast differences; whereas urinary excretion predominates in humans, chimps, rhesus monkeys, and guinea pigs; rats, hamsters, and mice show predominately fecal elimination. The difference among species seems due to capability of biliary excretion. A molecular weight threshold seems to exist, and this may account for the varying remnants of DES housed in different species' organs. Placental transfer is another major problem. Fetuses of many species seem capable of glucurondizing DES. The formation of reactive metabolites (i.e., affinity for estradiol 17-beta receptor attachment and affinity for other proteins bound by estrogen) through oxidative biotransformation suggests that DES metabolites affect hepatic systems and may activate or transform cells to malignancy. Theories of the organotropism of DES carcinogenicity are presented, as well as a discussion of the fate of DES in the environment." @default.
• W2203898014 created "2016-06-24" @default.
• W2203898014 creator A5020643249 @default.
• W2203898014 date "1981-01-01" @default.
• W2203898014 modified "2023-09-23" @default.
• W2203898014 title "The Metabolism of Diethylstilbestro" @default.
• W2203898014 cites W11961341 @default.
• W2203898014 cites W1501308548 @default.
• W2203898014 cites W1522421580 @default.
• W2203898014 cites W15668822 @default.
• W2203898014 cites W1882740056 @default.
• W2203898014 cites W190774094 @default.
• W2203898014 cites W1964745606 @default.
• W2203898014 cites W1973856086 @default.
• W2203898014 cites W1974420969 @default.
• W2203898014 cites W1975591617 @default.
• W2203898014 cites W1976653982 @default.
• W2203898014 cites W1976694429 @default.
• W2203898014 cites W1978613156 @default.
• W2203898014 cites W1980349595 @default.
• W2203898014 cites W1980992124 @default.
• W2203898014 cites W1985182742 @default.
• W2203898014 cites W1987354203 @default.
• W2203898014 cites W1987588527 @default.
• W2203898014 cites W1989403768 @default.
• W2203898014 cites W1991143827 @default.
• W2203898014 cites W1991377418 @default.
• W2203898014 cites W1993095465 @default.
• W2203898014 cites W1996046902 @default.
• W2203898014 cites W1996248208 @default.
• W2203898014 cites W1996692656 @default.
• W2203898014 cites W2000216270 @default.
• W2203898014 cites W2001715346 @default.
• W2203898014 cites W2002983696 @default.
• W2203898014 cites W2004340791 @default.
• W2203898014 cites W2006591487 @default.
• W2203898014 cites W2010281203 @default.
• W2203898014 cites W2012049474 @default.
• W2203898014 cites W2014227800 @default.
• W2203898014 cites W2019688740 @default.
• W2203898014 cites W2020530329 @default.
• W2203898014 cites W2022803751 @default.
• W2203898014 cites W2022852366 @default.
• W2203898014 cites W2024256159 @default.
• W2203898014 cites W2027571842 @default.
• W2203898014 cites W2034514356 @default.
• W2203898014 cites W2034683001 @default.
• W2203898014 cites W20355472 @default.
• W2203898014 cites W2041356813 @default.
• W2203898014 cites W2045045216 @default.
• W2203898014 cites W2045569437 @default.
• W2203898014 cites W2046007581 @default.
• W2203898014 cites W2050555889 @default.
• W2203898014 cites W2053693021 @default.
• W2203898014 cites W2058545087 @default.
• W2203898014 cites W2059897777 @default.
• W2203898014 cites W2067180546 @default.
• W2203898014 cites W2067268335 @default.
• W2203898014 cites W2074520623 @default.
• W2203898014 cites W2076285989 @default.
• W2203898014 cites W207967439 @default.
• W2203898014 cites W2083323499 @default.
• W2203898014 cites W2084108363 @default.
• W2203898014 cites W2085705037 @default.
• W2203898014 cites W2086455741 @default.
• W2203898014 cites W2088653659 @default.
• W2203898014 cites W2089863182 @default.
• W2203898014 cites W2092621457 @default.
• W2203898014 cites W2117578081 @default.
• W2203898014 cites W2118119297 @default.
• W2203898014 cites W2124814264 @default.
• W2203898014 cites W2139850550 @default.
• W2203898014 cites W2140296272 @default.
• W2203898014 cites W2141749673 @default.
• W2203898014 cites W2145639099 @default.
• W2203898014 cites W2153345710 @default.
• W2203898014 cites W2164815775 @default.
• W2203898014 cites W2204244505 @default.
• W2203898014 cites W2215173399 @default.
• W2203898014 cites W2225124630 @default.
• W2203898014 cites W2227369191 @default.
• W2203898014 cites W2227401248 @default.
• W2203898014 cites W2231063395 @default.
• W2203898014 cites W2280742343 @default.
• W2203898014 cites W2293218278 @default.
• W2203898014 cites W2312284329 @default.
• W2203898014 cites W2316273606 @default.
• W2203898014 cites W2319464440 @default.
• W2203898014 cites W2320408871 @default.
• W2203898014 cites W2320659059 @default.
• W2203898014 cites W2324178537 @default.
• W2203898014 cites W2327477593 @default.
• W2203898014 cites W2330465395 @default.
• W2203898014 cites W2339967897 @default.
• W2203898014 cites W2343430164 @default.
• W2203898014 cites W2345226980 @default.
• W2203898014 cites W2346021261 @default.
• W2203898014 cites W2346944741 @default.

• next