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- W2203933710 abstract "Significance The cell wall is an essential protective structure for bacteria, and the enzymes required for its biogenesis are the targets for many potent antibiotics. However, there is little knowledge of how bacteria (particularly Gram-negative organisms) respond to damage to the cell wall caused by antibiotics or other agents. Here, we describe a signaling system (the histidine kinase/response regulator pair WigKR) in Vibrio cholerae , the cholera pathogen that is triggered by antibiotics that disrupt various steps in cell wall synthesis. Activation of WigR leads to increased expression of genes required for cell wall synthesis and enables the pathogen to recover from the spherical nondividing state induced by antibiotics. Collectively, our findings reveal a new signal transduction pathway controlling cell wall biosynthesis and antibiotic tolerance." @default.
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- W2203933710 date "2015-12-28" @default.
- W2203933710 modified "2023-10-12" @default.
- W2203933710 title "A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance" @default.
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- W2203933710 doi "https://doi.org/10.1073/pnas.1520333113" @default.
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