FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2203934377> ?p ?o ?g. }

• W2203934377 abstract "The application of next-generation-sequencing based methods has recently allowed the sequence-specific occurrence of RNA modifications to be investigated in transcriptome-wide settings. This has led to the emergence of a new field of molecular genetics research termed epitranscriptomics. Investigations have shown that these modifications can exert control over protein synthesis via various mechanisms, and particularly when occurring on messenger RNAs, can be dynamically regulated. Here, we propose that RNA modifications may be a critical regulator over the spatiotemporal control of protein-synthesis in neurons, which is supported by our finding that the RNA methylase NSun2 colocalizes with the translational-repressor FMRP at neuronal dendrites. We also observe that NSun2 commonly methylates mRNAs which encode components of the postsynaptic proteome, and further find that NSun2 and FMRP likely share a common subset of mRNA targets which include those that are known to be translated at dendrites in an activity-dependent manner. We consider potential roles for RNA modifications in space- time- and activity-dependent regulation of protein synthesis in neuronal physiology, with a particular focus on synaptic plasticity modulation." @default.
• W2203934377 created "2016-06-24" @default.
• W2203934377 creator A5020935140 @default.
• W2203934377 creator A5069054132 @default.
• W2203934377 date "2015-10-31" @default.
• W2203934377 modified "2023-10-17" @default.
• W2203934377 title "The epitranscriptome in modulating spatiotemporal RNA translation in neuronal post-synaptic function" @default.
• W2203934377 cites W1572640432 @default.
• W2203934377 cites W1608464482 @default.
• W2203934377 cites W1652058896 @default.
• W2203934377 cites W1764846306 @default.
• W2203934377 cites W1790729219 @default.
• W2203934377 cites W1941339056 @default.
• W2203934377 cites W1965265446 @default.
• W2203934377 cites W1967232661 @default.
• W2203934377 cites W1970460195 @default.
• W2203934377 cites W1970826620 @default.
• W2203934377 cites W1971263143 @default.
• W2203934377 cites W1972148647 @default.
• W2203934377 cites W1979496428 @default.
• W2203934377 cites W1982749428 @default.
• W2203934377 cites W1991807334 @default.
• W2203934377 cites W2000434144 @default.
• W2203934377 cites W2001215117 @default.
• W2203934377 cites W2002364516 @default.
• W2203934377 cites W2003982930 @default.
• W2203934377 cites W2009138589 @default.
• W2203934377 cites W2009308529 @default.
• W2203934377 cites W2011131953 @default.
• W2203934377 cites W2011400542 @default.
• W2203934377 cites W2012010559 @default.
• W2203934377 cites W2014722170 @default.
• W2203934377 cites W2015696149 @default.
• W2203934377 cites W2018404810 @default.
• W2203934377 cites W2022268135 @default.
• W2203934377 cites W2022770379 @default.
• W2203934377 cites W2024090376 @default.
• W2203934377 cites W2025059121 @default.
• W2203934377 cites W2027699509 @default.
• W2203934377 cites W2028018746 @default.
• W2203934377 cites W2028230396 @default.
• W2203934377 cites W2031388575 @default.
• W2203934377 cites W2031779883 @default.
• W2203934377 cites W2031785254 @default.
• W2203934377 cites W2033159578 @default.
• W2203934377 cites W2036581163 @default.
• W2203934377 cites W2040485185 @default.
• W2203934377 cites W2042892138 @default.
• W2203934377 cites W2048862315 @default.
• W2203934377 cites W2050849480 @default.
• W2203934377 cites W2051737779 @default.
• W2203934377 cites W2052326665 @default.
• W2203934377 cites W2054855377 @default.
• W2203934377 cites W2055735408 @default.
• W2203934377 cites W2056922981 @default.
• W2203934377 cites W2058852389 @default.
• W2203934377 cites W2060902122 @default.
• W2203934377 cites W2064438779 @default.
• W2203934377 cites W2065847836 @default.
• W2203934377 cites W2067022150 @default.
• W2203934377 cites W2068904459 @default.
• W2203934377 cites W2071462537 @default.
• W2203934377 cites W2071849521 @default.
• W2203934377 cites W2071930821 @default.
• W2203934377 cites W2073175342 @default.
• W2203934377 cites W2073917895 @default.
• W2203934377 cites W2075839436 @default.
• W2203934377 cites W2076772609 @default.
• W2203934377 cites W2077060302 @default.
• W2203934377 cites W2078964320 @default.
• W2203934377 cites W2079517684 @default.
• W2203934377 cites W2080252952 @default.
• W2203934377 cites W2085398950 @default.
• W2203934377 cites W2085928743 @default.
• W2203934377 cites W2088242217 @default.
• W2203934377 cites W2089351762 @default.
• W2203934377 cites W2090183355 @default.
• W2203934377 cites W2091724447 @default.
• W2203934377 cites W2093242231 @default.
• W2203934377 cites W2094535741 @default.
• W2203934377 cites W2097812689 @default.
• W2203934377 cites W2105748760 @default.
• W2203934377 cites W2107190396 @default.
• W2203934377 cites W2116966832 @default.
• W2203934377 cites W2117038257 @default.
• W2203934377 cites W2120211068 @default.
• W2203934377 cites W2120805065 @default.
• W2203934377 cites W2122324193 @default.
• W2203934377 cites W2123824748 @default.
• W2203934377 cites W2127039851 @default.
• W2203934377 cites W2127802201 @default.
• W2203934377 cites W2128539037 @default.
• W2203934377 cites W2130745215 @default.
• W2203934377 cites W2131387714 @default.
• W2203934377 cites W2132762486 @default.
• W2203934377 cites W2141545756 @default.
• W2203934377 cites W2143801120 @default.
• W2203934377 cites W2143823065 @default.
• W2203934377 cites W2144403131 @default.
• W2203934377 cites W2147033427 @default.

• next